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Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review
Background: The most recommended treatment for a Helicobacter pylori infection is high doses of combined antibiotics. The objective of this article is to perform a systematic review of the economic evaluation studies applied to assess the efficiency of diagnostic testing for H. pylori infections, so...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827917/ https://www.ncbi.nlm.nih.gov/pubmed/33430005 http://dx.doi.org/10.3390/antibiotics10010055 |
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author | Rojas García, Paula van der Pol, Simon van Asselt, Antoinette D. I. Postma, Maarten Rodríguez-Ibeas, Roberto Juárez-Castelló, Carmelo A. González, Marino Antoñanzas, Fernando |
author_facet | Rojas García, Paula van der Pol, Simon van Asselt, Antoinette D. I. Postma, Maarten Rodríguez-Ibeas, Roberto Juárez-Castelló, Carmelo A. González, Marino Antoñanzas, Fernando |
author_sort | Rojas García, Paula |
collection | PubMed |
description | Background: The most recommended treatment for a Helicobacter pylori infection is high doses of combined antibiotics. The objective of this article is to perform a systematic review of the economic evaluation studies applied to assess the efficiency of diagnostic testing for H. pylori infections, so that their main characteristics can be identified and to learn from the literature how the antimicrobial resistance (AMR) issue is incorporated into these economic evaluations. Methods: We conducted a systematic review to compare the costs and clinical effectiveness of diagnostic strategies for H. pylori infections. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and extracted the items from the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: We found thirteen articles that were of good quality according to CHEERS: six studies focused on diagnostics of Helicobacter pylori infections associated with dyspepsia and four on duodenal ulcers. Testing was found to be the most cost-effective strategy in eight articles. Four studies considered AMR. Conclusions: Testing was more cost-effective than empirical treatment, except in cases of high prevalence (as with developing countries) or when patients could be stratified according to their comorbidities. The introduction of AMR into the model may change the efficiency of the testing strategy. |
format | Online Article Text |
id | pubmed-7827917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78279172021-01-25 Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review Rojas García, Paula van der Pol, Simon van Asselt, Antoinette D. I. Postma, Maarten Rodríguez-Ibeas, Roberto Juárez-Castelló, Carmelo A. González, Marino Antoñanzas, Fernando Antibiotics (Basel) Review Background: The most recommended treatment for a Helicobacter pylori infection is high doses of combined antibiotics. The objective of this article is to perform a systematic review of the economic evaluation studies applied to assess the efficiency of diagnostic testing for H. pylori infections, so that their main characteristics can be identified and to learn from the literature how the antimicrobial resistance (AMR) issue is incorporated into these economic evaluations. Methods: We conducted a systematic review to compare the costs and clinical effectiveness of diagnostic strategies for H. pylori infections. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and extracted the items from the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: We found thirteen articles that were of good quality according to CHEERS: six studies focused on diagnostics of Helicobacter pylori infections associated with dyspepsia and four on duodenal ulcers. Testing was found to be the most cost-effective strategy in eight articles. Four studies considered AMR. Conclusions: Testing was more cost-effective than empirical treatment, except in cases of high prevalence (as with developing countries) or when patients could be stratified according to their comorbidities. The introduction of AMR into the model may change the efficiency of the testing strategy. MDPI 2021-01-08 /pmc/articles/PMC7827917/ /pubmed/33430005 http://dx.doi.org/10.3390/antibiotics10010055 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rojas García, Paula van der Pol, Simon van Asselt, Antoinette D. I. Postma, Maarten Rodríguez-Ibeas, Roberto Juárez-Castelló, Carmelo A. González, Marino Antoñanzas, Fernando Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review |
title | Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review |
title_full | Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review |
title_fullStr | Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review |
title_full_unstemmed | Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review |
title_short | Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review |
title_sort | efficiency of diagnostic testing for helicobacter pylori infections—a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827917/ https://www.ncbi.nlm.nih.gov/pubmed/33430005 http://dx.doi.org/10.3390/antibiotics10010055 |
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