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Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy

The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways. Recent evidence shows that the crucial components o...

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Detalles Bibliográficos
Autores principales: Lan, Tianxia, Chen, Li, Wei, Xiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827947/
https://www.ncbi.nlm.nih.gov/pubmed/33429846
http://dx.doi.org/10.3390/cells10010100
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author Lan, Tianxia
Chen, Li
Wei, Xiawei
author_facet Lan, Tianxia
Chen, Li
Wei, Xiawei
author_sort Lan, Tianxia
collection PubMed
description The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways. Recent evidence shows that the crucial components of cancer-related inflammation are involved in a coordinated system to influence the development of cancer, which may shed light on the development of potential anticancer therapies. Since the last century, considerable effort has been devoted to developing gene therapies for life-threatening diseases. When it comes to modulating the inflammatory microenvironment for cancer therapy, inflammatory cytokines are the most efficient targets. In this manuscript, we provide a comprehensive review of the relationship between inflammation and cancer development, especially focusing on inflammatory cytokines. We also summarize the clinical trials for gene therapy targeting inflammatory cytokines for cancer treatment. Future perspectives concerned with new gene-editing technology and novel gene delivery systems are finally provided.
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spelling pubmed-78279472021-01-25 Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy Lan, Tianxia Chen, Li Wei, Xiawei Cells Review The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways. Recent evidence shows that the crucial components of cancer-related inflammation are involved in a coordinated system to influence the development of cancer, which may shed light on the development of potential anticancer therapies. Since the last century, considerable effort has been devoted to developing gene therapies for life-threatening diseases. When it comes to modulating the inflammatory microenvironment for cancer therapy, inflammatory cytokines are the most efficient targets. In this manuscript, we provide a comprehensive review of the relationship between inflammation and cancer development, especially focusing on inflammatory cytokines. We also summarize the clinical trials for gene therapy targeting inflammatory cytokines for cancer treatment. Future perspectives concerned with new gene-editing technology and novel gene delivery systems are finally provided. MDPI 2021-01-08 /pmc/articles/PMC7827947/ /pubmed/33429846 http://dx.doi.org/10.3390/cells10010100 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lan, Tianxia
Chen, Li
Wei, Xiawei
Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
title Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
title_full Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
title_fullStr Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
title_full_unstemmed Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
title_short Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
title_sort inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827947/
https://www.ncbi.nlm.nih.gov/pubmed/33429846
http://dx.doi.org/10.3390/cells10010100
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