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Magnetic Hyperthermia on γ-Fe(2)O(3)@SiO(2) Core-Shell Nanoparticles for mi-RNA 122 Detection

Magnetic hyperthermia on core-shell nanoparticles bears promising achievements, especially in biomedical applications. Here, thanks to magnetic hyperthermia, γ-Fe(2)O(3) cores are able to release a DNA target mimicking the liver specific oncotarget miRNA-122. Our silica coated magnetic nanoparticles...

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Detalles Bibliográficos
Autores principales: Horny, Marie-Charlotte, Gamby, Jean, Dupuis, Vincent, Siaugue, Jean-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828054/
https://www.ncbi.nlm.nih.gov/pubmed/33435365
http://dx.doi.org/10.3390/nano11010149
Descripción
Sumario:Magnetic hyperthermia on core-shell nanoparticles bears promising achievements, especially in biomedical applications. Here, thanks to magnetic hyperthermia, γ-Fe(2)O(3) cores are able to release a DNA target mimicking the liver specific oncotarget miRNA-122. Our silica coated magnetic nanoparticles not only allow the grafting at their surface of a significant number of oligonucleotides but are also shown to be as efficient, by local heating, as 95 °C global heating when submitted to an alternative magnetic field, while keeping the solution at 28 °C, crucial for biological media and energy efficiency. Moreover, a slight modification of the silica coating process revealed an increased heating power, well adapted for the release of small oligonucleotides such as microRNA.