Cargando…

An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer

SIMPLE SUMMARY: Pancreatic cancer refers to a group of malignancies of which pancreatic ductal adenocarcinoma (PDAC) is the most common form. It is an aggressive tumour with few treatment options and very poor outcomes. There is an unmet need for novel targeted therapies for PDAC. In this regard, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Robinson, Claire M., Talty, Aaron, Logue, Susan E., Mnich, Katarzyna, Gorman, Adrienne M., Samali, Afshin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828145/ https://www.ncbi.nlm.nih.gov/pubmed/33445669 http://dx.doi.org/10.3390/cancers13020261

Ejemplares similares

The Unfolded Protein Response in Breast Cancer
por: McGrath, Eoghan P., et al.
Publicado: (2018)

Regulation of lipid metabolism by the unfolded protein response
por: Moncan, Matthieu, et al.
Publicado: (2021)

Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β
por: Talty, Aaron, et al.
Publicado: (2019)

Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β
por: Talty, Aaron, et al.
Publicado: (2020)

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
por: Doyle, Karen M, et al.
Publicado: (2011)

New insights into IRE1α activation and function in anti-tumor immunity
por: Logue, Susan E., et al.
Publicado: (2022)

The stressosome, a caspase‐8‐activating signalling complex assembled in response to cell stress in an ATG5‐mediated manner
por: Mnich, Katarzyna, et al.
Publicado: (2021)

Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1
por: Creedican, Stuart, et al.
Publicado: (2019)

Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
por: Samali, Afshin, et al.
Publicado: (2010)

Drugging the unfolded protein response in acute leukemias
por: Kharabi Masouleh, Behzad, et al.
Publicado: (2015)

Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion
por: Cawley, Karen, et al.
Publicado: (2013)

Cellular Stress Responses: Cell Survival and Cell Death
por: Fulda, Simone, et al.
Publicado: (2010)

miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts
por: Read, Danielle E, et al.
Publicado: (2014)

Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM
por: Kennedy, Donna, et al.
Publicado: (2014)

Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis
por: Sharma, Pawan, et al.
Publicado: (2021)

Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells
por: Dastghaib, Sanaz, et al.
Publicado: (2020)

Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis
por: Read, Danielle E., et al.
Publicado: (2021)

Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson’s Disease
por: Mnich, Katarzyna, et al.
Publicado: (2022)

Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival
por: Saveljeva, Svetlana, et al.
Publicado: (2016)

Pancreatic Adaptive Responses in Alcohol Abuse: Role of the Unfolded Protein Response
por: Lugea, Aurelia, et al.
Publicado: (2015)

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
por: Mahameed, Mohamed, et al.
Publicado: (2019)

PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response
por: Gupta, Ananya, et al.
Publicado: (2015)

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
por: Logue, Susan E., et al.
Publicado: (2018)

Cell Stress and Cell Death
por: Samali, Afshin, et al.
Publicado: (2010)

Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors
por: Carlesso, Antonio, et al.
Publicado: (2019)

Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain
por: Carlesso, Antonio, et al.
Publicado: (2018)

Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling
por: Carlesso, Antonio, et al.
Publicado: (2019)

Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1
por: Chintha, Chetan, et al.
Publicado: (2020)

The role of the unfolded protein response in myelination
por: Naughton, Michelle C., et al.
Publicado: (2016)

Insights into the structure and function of the RNA ligase RtcB
por: Moncan, Matthieu, et al.
Publicado: (2023)

Inhibition of IRE1α RNase activity sensitizes patient‐derived acute myeloid leukaemia cells to proteasome inhibitors
por: Creedican, Stuart, et al.
Publicado: (2022)

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer
por: Almanza, Aitor, et al.
Publicado: (2022)

Unfolded Protein Responses With or Without Unfolded Proteins?
por: Snapp, Erik L.
Publicado: (2012)

The role of the unfolded protein response in arrhythmias
por: Liu, Man, et al.
Publicado: (2018)

Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress
por: Ong, Gideon, et al.
Publicado: (2023)

Protective Unfolded Protein Response in Human Pancreatic Beta Cells Transplanted into Mice
por: Kennedy, Jeffrey, et al.
Publicado: (2010)

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis
por: Kennedy, Donna, et al.
Publicado: (2017)

The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration
por: Perri, Emma R., et al.
Publicado: (2016)

The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation
por: Fernández, Dominique, et al.
Publicado: (2021)

The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells
por: Su, Hsin-Yuan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_o7f66v52k64vq2dsf4j9a1n4hm