Cargando…

Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study

Duplicated Heschl’s gyrus (HG) is prevalent in patients with schizophrenia and may reflect early neurodevelopmental anomalies. However, it currently remains unclear whether patients with schizotypal disorder, a prototypic disorder within the schizophrenia spectrum, exhibit a similar HG gyrification...

Descripción completa

Detalles Bibliográficos
Autores principales: Takahashi, Tsutomu, Sasabayashi, Daiki, Takayanagi, Yoichiro, Furuichi, Atsushi, Kido, Mikio, Pham, Tien Viet, Kobayashi, Haruko, Noguchi, Kyo, Suzuki, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828168/
https://www.ncbi.nlm.nih.gov/pubmed/33445715
http://dx.doi.org/10.3390/jpm11010040
_version_ 1783640945616486400
author Takahashi, Tsutomu
Sasabayashi, Daiki
Takayanagi, Yoichiro
Furuichi, Atsushi
Kido, Mikio
Pham, Tien Viet
Kobayashi, Haruko
Noguchi, Kyo
Suzuki, Michio
author_facet Takahashi, Tsutomu
Sasabayashi, Daiki
Takayanagi, Yoichiro
Furuichi, Atsushi
Kido, Mikio
Pham, Tien Viet
Kobayashi, Haruko
Noguchi, Kyo
Suzuki, Michio
author_sort Takahashi, Tsutomu
collection PubMed
description Duplicated Heschl’s gyrus (HG) is prevalent in patients with schizophrenia and may reflect early neurodevelopmental anomalies. However, it currently remains unclear whether patients with schizotypal disorder, a prototypic disorder within the schizophrenia spectrum, exhibit a similar HG gyrification pattern. In this magnetic resonance imaging study, HG gyrification patterns were examined in 47 patients with schizotypal disorder, 111 with schizophrenia, and 88 age- and sex-matched healthy subjects. HG gyrification patterns were classified as single, common stem duplication (CSD), or complete posterior duplication (CPD). The prevalence of the duplicated HG patterns (CSD or CPD) bilaterally was higher in the schizophrenia and schizotypal groups than in healthy controls, whereas no significant difference was observed between the schizophrenia and schizotypal groups. Schizophrenia patients with the right CPD pattern had less severe positive symptoms, whereas the right single HG pattern was associated with higher doses of antipsychotic medication in schizotypal patients. The present study demonstrated shared HG gyrification patterns in schizophrenia spectrum disorders, which may reflect a common biological vulnerability factor. HG patterns may also be associated with susceptibility to psychopathology.
format Online
Article
Text
id pubmed-7828168
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78281682021-01-25 Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study Takahashi, Tsutomu Sasabayashi, Daiki Takayanagi, Yoichiro Furuichi, Atsushi Kido, Mikio Pham, Tien Viet Kobayashi, Haruko Noguchi, Kyo Suzuki, Michio J Pers Med Article Duplicated Heschl’s gyrus (HG) is prevalent in patients with schizophrenia and may reflect early neurodevelopmental anomalies. However, it currently remains unclear whether patients with schizotypal disorder, a prototypic disorder within the schizophrenia spectrum, exhibit a similar HG gyrification pattern. In this magnetic resonance imaging study, HG gyrification patterns were examined in 47 patients with schizotypal disorder, 111 with schizophrenia, and 88 age- and sex-matched healthy subjects. HG gyrification patterns were classified as single, common stem duplication (CSD), or complete posterior duplication (CPD). The prevalence of the duplicated HG patterns (CSD or CPD) bilaterally was higher in the schizophrenia and schizotypal groups than in healthy controls, whereas no significant difference was observed between the schizophrenia and schizotypal groups. Schizophrenia patients with the right CPD pattern had less severe positive symptoms, whereas the right single HG pattern was associated with higher doses of antipsychotic medication in schizotypal patients. The present study demonstrated shared HG gyrification patterns in schizophrenia spectrum disorders, which may reflect a common biological vulnerability factor. HG patterns may also be associated with susceptibility to psychopathology. MDPI 2021-01-12 /pmc/articles/PMC7828168/ /pubmed/33445715 http://dx.doi.org/10.3390/jpm11010040 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takahashi, Tsutomu
Sasabayashi, Daiki
Takayanagi, Yoichiro
Furuichi, Atsushi
Kido, Mikio
Pham, Tien Viet
Kobayashi, Haruko
Noguchi, Kyo
Suzuki, Michio
Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study
title Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study
title_full Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study
title_fullStr Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study
title_full_unstemmed Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study
title_short Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study
title_sort increased heschl’s gyrus duplication in schizophrenia spectrum disorders: a cross-sectional mri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828168/
https://www.ncbi.nlm.nih.gov/pubmed/33445715
http://dx.doi.org/10.3390/jpm11010040
work_keys_str_mv AT takahashitsutomu increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy
AT sasabayashidaiki increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy
AT takayanagiyoichiro increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy
AT furuichiatsushi increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy
AT kidomikio increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy
AT phamtienviet increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy
AT kobayashiharuko increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy
AT noguchikyo increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy
AT suzukimichio increasedheschlsgyrusduplicationinschizophreniaspectrumdisordersacrosssectionalmristudy