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COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles

COVID-19 pandemic will continue to pose a major public health threat until vaccination-mediated herd immunity is achieved. Most projections predict vaccines will reach a large subset of the population late in 2021 or early 2022. In the meantime, countries are exploring options to remove strict lockd...

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Detalles Bibliográficos
Autores principales: Ghaffari, Abdi, Meurant, Robyn, Ardakani, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828180/
https://www.ncbi.nlm.nih.gov/pubmed/33445727
http://dx.doi.org/10.3390/diagnostics11010115
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author Ghaffari, Abdi
Meurant, Robyn
Ardakani, Ali
author_facet Ghaffari, Abdi
Meurant, Robyn
Ardakani, Ali
author_sort Ghaffari, Abdi
collection PubMed
description COVID-19 pandemic will continue to pose a major public health threat until vaccination-mediated herd immunity is achieved. Most projections predict vaccines will reach a large subset of the population late in 2021 or early 2022. In the meantime, countries are exploring options to remove strict lockdown measures and allow society and the economy to return to normal function. One possibility is to expand on existing COVID-19 testing strategies by including large-scale rapid point-of-care diagnostic tests (POCTs). Currently, there is significant variability in performance and features of available POCTs, making selection and procurement of an appropriate test for specific use case difficult. In this review, we have used the World Health Organization’s (WHO) recently published target product profiles (TPPs) for specific use cases of COVID-19 diagnostic tests to screen for top-performing POCTs on the market. Several POCTs, based on clinical sensitivity/specificity, the limit of detection, and time to results, which meet WHO TPP criteria for direct detection of SARS-CoV-2 (acute infection) or indirect diagnosis of past infection (host antibodies), are highlighted here.
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spelling pubmed-78281802021-01-25 COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles Ghaffari, Abdi Meurant, Robyn Ardakani, Ali Diagnostics (Basel) Review COVID-19 pandemic will continue to pose a major public health threat until vaccination-mediated herd immunity is achieved. Most projections predict vaccines will reach a large subset of the population late in 2021 or early 2022. In the meantime, countries are exploring options to remove strict lockdown measures and allow society and the economy to return to normal function. One possibility is to expand on existing COVID-19 testing strategies by including large-scale rapid point-of-care diagnostic tests (POCTs). Currently, there is significant variability in performance and features of available POCTs, making selection and procurement of an appropriate test for specific use case difficult. In this review, we have used the World Health Organization’s (WHO) recently published target product profiles (TPPs) for specific use cases of COVID-19 diagnostic tests to screen for top-performing POCTs on the market. Several POCTs, based on clinical sensitivity/specificity, the limit of detection, and time to results, which meet WHO TPP criteria for direct detection of SARS-CoV-2 (acute infection) or indirect diagnosis of past infection (host antibodies), are highlighted here. MDPI 2021-01-12 /pmc/articles/PMC7828180/ /pubmed/33445727 http://dx.doi.org/10.3390/diagnostics11010115 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghaffari, Abdi
Meurant, Robyn
Ardakani, Ali
COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles
title COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles
title_full COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles
title_fullStr COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles
title_full_unstemmed COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles
title_short COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles
title_sort covid-19 point-of-care diagnostics that satisfy global target product profiles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828180/
https://www.ncbi.nlm.nih.gov/pubmed/33445727
http://dx.doi.org/10.3390/diagnostics11010115
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