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Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine with antioxidant, chronobiotic and anti-inflammatory properties; reduced levels of this hormone are associated with higher risk of cancer. Several beneficial effects of melatonin have been described in a broad number of tumors, including liv...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828223/ https://www.ncbi.nlm.nih.gov/pubmed/33445767 http://dx.doi.org/10.3390/antiox10010103 |
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author | Fernández-Palanca, Paula Méndez-Blanco, Carolina Fondevila, Flavia Tuñón, María J. Reiter, Russel J. Mauriz, José L. González-Gallego, Javier |
author_facet | Fernández-Palanca, Paula Méndez-Blanco, Carolina Fondevila, Flavia Tuñón, María J. Reiter, Russel J. Mauriz, José L. González-Gallego, Javier |
author_sort | Fernández-Palanca, Paula |
collection | PubMed |
description | Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine with antioxidant, chronobiotic and anti-inflammatory properties; reduced levels of this hormone are associated with higher risk of cancer. Several beneficial effects of melatonin have been described in a broad number of tumors, including liver cancers. In this work we systematically reviewed the publications of the last 15 years that assessed the underlying mechanisms of melatonin activities against liver cancers, and its role as coadjuvant in the treatment of these tumors. Literature research was performed employing PubMed, Scopus and Web of Science (WOS) databases and, after screening, 51 articles were included. Results from the selected studies denoted the useful actions of melatonin in preventing carcinogenesis and as a promising treatment option for the primary liver tumors hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), either alone or in combination with other compounds. Different processes were modulated by the indole, such as inhibition of oxidative stress, proliferation, angiogenesis and invasion, promotion of immune system response, cell cycle arrest and apoptosis, as well as recovery of circadian rhythms and autophagy modulation. Taken together, the present systematic review highlights the evidence that document the potential role of melatonin in improving the landscape of liver tumor treatment. |
format | Online Article Text |
id | pubmed-7828223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78282232021-01-25 Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review Fernández-Palanca, Paula Méndez-Blanco, Carolina Fondevila, Flavia Tuñón, María J. Reiter, Russel J. Mauriz, José L. González-Gallego, Javier Antioxidants (Basel) Review Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine with antioxidant, chronobiotic and anti-inflammatory properties; reduced levels of this hormone are associated with higher risk of cancer. Several beneficial effects of melatonin have been described in a broad number of tumors, including liver cancers. In this work we systematically reviewed the publications of the last 15 years that assessed the underlying mechanisms of melatonin activities against liver cancers, and its role as coadjuvant in the treatment of these tumors. Literature research was performed employing PubMed, Scopus and Web of Science (WOS) databases and, after screening, 51 articles were included. Results from the selected studies denoted the useful actions of melatonin in preventing carcinogenesis and as a promising treatment option for the primary liver tumors hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), either alone or in combination with other compounds. Different processes were modulated by the indole, such as inhibition of oxidative stress, proliferation, angiogenesis and invasion, promotion of immune system response, cell cycle arrest and apoptosis, as well as recovery of circadian rhythms and autophagy modulation. Taken together, the present systematic review highlights the evidence that document the potential role of melatonin in improving the landscape of liver tumor treatment. MDPI 2021-01-12 /pmc/articles/PMC7828223/ /pubmed/33445767 http://dx.doi.org/10.3390/antiox10010103 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fernández-Palanca, Paula Méndez-Blanco, Carolina Fondevila, Flavia Tuñón, María J. Reiter, Russel J. Mauriz, José L. González-Gallego, Javier Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review |
title | Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review |
title_full | Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review |
title_fullStr | Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review |
title_full_unstemmed | Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review |
title_short | Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review |
title_sort | melatonin as an antitumor agent against liver cancer: an updated systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828223/ https://www.ncbi.nlm.nih.gov/pubmed/33445767 http://dx.doi.org/10.3390/antiox10010103 |
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