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Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia

Neonatal encephalopathy (NE) is a global burden, as more than 90% of NE occurs in low- and middle-income countries (LMICs). Perinatal infection seems to limit the neuroprotective efficacy of therapeutic hypothermia. Efforts made to use therapeutic hypothermia in LMICs treating NE has led to increase...

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Detalles Bibliográficos
Autores principales: Danladi, Jibrin, Sabir, Hemmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828225/
https://www.ncbi.nlm.nih.gov/pubmed/33445791
http://dx.doi.org/10.3390/ijms22020707
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author Danladi, Jibrin
Sabir, Hemmen
author_facet Danladi, Jibrin
Sabir, Hemmen
author_sort Danladi, Jibrin
collection PubMed
description Neonatal encephalopathy (NE) is a global burden, as more than 90% of NE occurs in low- and middle-income countries (LMICs). Perinatal infection seems to limit the neuroprotective efficacy of therapeutic hypothermia. Efforts made to use therapeutic hypothermia in LMICs treating NE has led to increased neonatal mortality rates. The heat shock and cold shock protein responses are essential for survival against a wide range of stressors during which organisms raise their core body temperature and temporarily subject themselves to thermal and cold stress in the face of infection. The characteristic increase and decrease in core body temperature activates and utilizes elements of the heat shock and cold shock response pathways to modify cytokine and chemokine gene expression, cellular signaling, and immune cell mobilization to sites of inflammation, infection, and injury. Hypothermia stimulates microglia to secret cold-inducible RNA-binding protein (CIRP), which triggers NF-κB, controlling multiple inflammatory pathways, including nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasomes and cyclooxygenase-2 (COX-2) signaling. Brain responses through changes in heat shock protein and cold shock protein transcription and gene-expression following fever range and hyperthermia may be new promising potential therapeutic targets.
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spelling pubmed-78282252021-01-25 Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia Danladi, Jibrin Sabir, Hemmen Int J Mol Sci Review Neonatal encephalopathy (NE) is a global burden, as more than 90% of NE occurs in low- and middle-income countries (LMICs). Perinatal infection seems to limit the neuroprotective efficacy of therapeutic hypothermia. Efforts made to use therapeutic hypothermia in LMICs treating NE has led to increased neonatal mortality rates. The heat shock and cold shock protein responses are essential for survival against a wide range of stressors during which organisms raise their core body temperature and temporarily subject themselves to thermal and cold stress in the face of infection. The characteristic increase and decrease in core body temperature activates and utilizes elements of the heat shock and cold shock response pathways to modify cytokine and chemokine gene expression, cellular signaling, and immune cell mobilization to sites of inflammation, infection, and injury. Hypothermia stimulates microglia to secret cold-inducible RNA-binding protein (CIRP), which triggers NF-κB, controlling multiple inflammatory pathways, including nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasomes and cyclooxygenase-2 (COX-2) signaling. Brain responses through changes in heat shock protein and cold shock protein transcription and gene-expression following fever range and hyperthermia may be new promising potential therapeutic targets. MDPI 2021-01-12 /pmc/articles/PMC7828225/ /pubmed/33445791 http://dx.doi.org/10.3390/ijms22020707 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Danladi, Jibrin
Sabir, Hemmen
Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia
title Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia
title_full Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia
title_fullStr Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia
title_full_unstemmed Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia
title_short Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia
title_sort perinatal infection: a major contributor to efficacy of cooling in newborns following birth asphyxia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828225/
https://www.ncbi.nlm.nih.gov/pubmed/33445791
http://dx.doi.org/10.3390/ijms22020707
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