Cargando…

Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson’s Disease

Lewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. Therefore, we analyzed the expression of five alpha-synuclein gene (SNCA) transcri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marsal-García, Laura, Urbizu, Aintzane, Arnaldo, Laura, Campdelacreu, Jaume, Vilas, Dolores, Ispierto, Lourdes, Gascón-Bayarri, Jordi, Reñé, Ramón, Álvarez, Ramiro, Beyer, Katrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828374/ https://www.ncbi.nlm.nih.gov/pubmed/33450872 http://dx.doi.org/10.3390/ijms22020725

Ejemplares similares

Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease
por: Gámez-Valero, Ana, et al.
Publicado: (2021)

Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood
por: Perez-Roca, Laia, et al.
Publicado: (2018)

Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies
por: Gámez-Valero, Ana, et al.
Publicado: (2019)

Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy
por: Urbizu, Aintzane, et al.
Publicado: (2020)

Obtaining miRNA from Saliva—Comparison of Sampling and Purification Methods
por: Urbizu, Aintzane, et al.
Publicado: (2023)

Severe Hyperammonemia in Late-Onset Ornithine Transcarbamylase Deficiency Triggered by Steroid Administration
por: Gascon-Bayarri, Jordi, et al.
Publicado: (2015)

Unusual Forehead Tremor in Four Patients with Essential Tremor
por: Gascón-Bayarri, Jordi, et al.
Publicado: (2012)

Comprehensive proteomic profiling of plasma-derived Extracellular Vesicles from dementia with Lewy Bodies patients
por: Gámez-Valero, Ana, et al.
Publicado: (2019)

Alpha-synuclein biology in Lewy body diseases
por: Kim, Woojin Scott, et al.
Publicado: (2014)

Protein Clearance Mechanisms of Alpha-Synuclein and Amyloid-Beta in Lewy Body Disorders
por: Deleidi, Michela, et al.
Publicado: (2012)

Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders
por: Manzanza, Nelson de Oliveira, et al.
Publicado: (2021)

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
por: Koss, David J., et al.
Publicado: (2022)

Alternative Splicing of Alpha- and Beta-Synuclein Genes Plays Differential Roles in Synucleinopathies
por: Gámez-Valero, Ana, et al.
Publicado: (2018)

Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies
por: Corbillé, Anne-Gaëlle, et al.
Publicado: (2016)

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
por: Ingelsson, Martin
Publicado: (2016)

The Contribution of Tau, Amyloid-Beta and Alpha-Synuclein Pathology to Dementia in Lewy Body Disorders
por: Irwin, David J., et al.
Publicado: (2018)

Alpha-synuclein seeds in olfactory mucosa and cerebrospinal fluid of patients with dementia with Lewy bodies
por: Perra, Daniela, et al.
Publicado: (2021)

Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
por: Sekiya, Hiroaki, et al.
Publicado: (2022)

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue
por: Dhavale, Dhruva D., et al.
Publicado: (2023)

Absence of Alpha-Synuclein Pathology in the Stomach of a Patient With Prodromal Dementia With Lewy Bodies
por: Shin, Chaewon, et al.
Publicado: (2023)

Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders
por: Altay, Melek Firat, et al.
Publicado: (2022)

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
por: Duffy, Megan F., et al.
Publicado: (2018)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
por: Masliah, Eliezer, et al.
Publicado: (2011)

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
por: Duffy, Megan F., et al.
Publicado: (2018)

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
por: Schaser, Allison J., et al.
Publicado: (2019)

Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro
por: Marotta, Nicholas P., et al.
Publicado: (2021)

Influence of RNA interference on the mitochondrial subcellular localization of alpha-synuclein and on the formation of Lewy body-like inclusions in the cytoplasm of human embryonic kidney 293 cells induced by the overexpression of alpha-synuclein☆
por: Chen, Tao, et al.
Publicado: (2012)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism
por: Osterberg, Valerie R., et al.
Publicado: (2015)

Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies
por: Bargar, Connor, et al.
Publicado: (2021)

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders
por: Kurzawa-Akanbi, Marzena, et al.
Publicado: (2021)

Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies
por: Brockmann, Kathrin, et al.
Publicado: (2021)

SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro
por: Wu, Zhengcun, et al.
Publicado: (2022)

Cerebrospinal Fluid Alpha-Synuclein Improves the Differentiation between Dementia with Lewy Bodies and Alzheimer’s Disease in Clinical Practice
por: Lilamand, Matthieu, et al.
Publicado: (2022)

Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders
por: Bräuer, Stefan, et al.
Publicado: (2023)

Periaqueductal gray matter echogenicity as a marker of migraine chronification: a case control study
por: Vilas, Dolores, et al.
Publicado: (2023)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies
por: Marschallinger, Julia, et al.
Publicado: (2020)

13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
por: Barclay, Alexander M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_co0lge1bi8g8m5n4kctmsvhofk