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Strategies to Better Target Fungal Squalene Monooxygenase
Fungal pathogens present a challenge in medicine and agriculture. They also harm ecosystems and threaten biodiversity. The allylamine class of antimycotics targets the enzyme squalene monooxygenase. This enzyme occupies a key position in the sterol biosynthesis pathway in eukaryotes, catalyzing the...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828399/ https://www.ncbi.nlm.nih.gov/pubmed/33450973 http://dx.doi.org/10.3390/jof7010049 |
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author | Sagatova, Alia A. |
author_facet | Sagatova, Alia A. |
author_sort | Sagatova, Alia A. |
collection | PubMed |
description | Fungal pathogens present a challenge in medicine and agriculture. They also harm ecosystems and threaten biodiversity. The allylamine class of antimycotics targets the enzyme squalene monooxygenase. This enzyme occupies a key position in the sterol biosynthesis pathway in eukaryotes, catalyzing the rate-limiting reaction by introducing an oxygen atom to the squalene substrate converting it to 2,3-oxidosqualene. Currently, terbinafine—the most widely used allylamine—is mostly used for treating superficial fungal infections. The ability to better target this enzyme will have significant implications for human health in the treatment of fungal infections. The human orthologue can also be targeted for cholesterol-lowering therapeutics and in cancer therapies. This review will focus on the structural basis for improving the current therapeutics for fungal squalene monooxygenase. |
format | Online Article Text |
id | pubmed-7828399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78283992021-01-25 Strategies to Better Target Fungal Squalene Monooxygenase Sagatova, Alia A. J Fungi (Basel) Review Fungal pathogens present a challenge in medicine and agriculture. They also harm ecosystems and threaten biodiversity. The allylamine class of antimycotics targets the enzyme squalene monooxygenase. This enzyme occupies a key position in the sterol biosynthesis pathway in eukaryotes, catalyzing the rate-limiting reaction by introducing an oxygen atom to the squalene substrate converting it to 2,3-oxidosqualene. Currently, terbinafine—the most widely used allylamine—is mostly used for treating superficial fungal infections. The ability to better target this enzyme will have significant implications for human health in the treatment of fungal infections. The human orthologue can also be targeted for cholesterol-lowering therapeutics and in cancer therapies. This review will focus on the structural basis for improving the current therapeutics for fungal squalene monooxygenase. MDPI 2021-01-13 /pmc/articles/PMC7828399/ /pubmed/33450973 http://dx.doi.org/10.3390/jof7010049 Text en © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sagatova, Alia A. Strategies to Better Target Fungal Squalene Monooxygenase |
title | Strategies to Better Target Fungal Squalene Monooxygenase |
title_full | Strategies to Better Target Fungal Squalene Monooxygenase |
title_fullStr | Strategies to Better Target Fungal Squalene Monooxygenase |
title_full_unstemmed | Strategies to Better Target Fungal Squalene Monooxygenase |
title_short | Strategies to Better Target Fungal Squalene Monooxygenase |
title_sort | strategies to better target fungal squalene monooxygenase |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828399/ https://www.ncbi.nlm.nih.gov/pubmed/33450973 http://dx.doi.org/10.3390/jof7010049 |
work_keys_str_mv | AT sagatovaaliaa strategiestobettertargetfungalsqualenemonooxygenase |