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Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

The solubility and dissolution thermodynamics of new c-Met inhibitor, ABN401, were determined in eleven solvents and Transcutol(®) HP–water mixture (TWM) from 298.15 to 318.15 K. The experimental solubilities were validated using five mathematical models, namely modified Apelblat, van’t Hoff, Buchow...

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Detalles Bibliográficos
Autores principales:	Ravi, Maharjan, Julu, Tripathi, Kim, Nam Ah, Park, Kyeung Eui, Jeong, Seong Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828412/ https://www.ncbi.nlm.nih.gov/pubmed/33450987 http://dx.doi.org/10.3390/molecules26020390

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