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Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis

Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g...

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Detalles Bibliográficos
Autores principales: Hagaman, Daniel E., Damasco, Jossana A., Perez, Joy Vanessa D., Rojo, Raniv D., Melancon, Marites P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828457/
https://www.ncbi.nlm.nih.gov/pubmed/33450939
http://dx.doi.org/10.3390/molecules26020384
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author Hagaman, Daniel E.
Damasco, Jossana A.
Perez, Joy Vanessa D.
Rojo, Raniv D.
Melancon, Marites P.
author_facet Hagaman, Daniel E.
Damasco, Jossana A.
Perez, Joy Vanessa D.
Rojo, Raniv D.
Melancon, Marites P.
author_sort Hagaman, Daniel E.
collection PubMed
description Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed. Nanotechnology is a versatile platform that has been used to increase the specificity and therapeutic efficacy of various treatments for prostate cancer bone metastases. In this review, we summarize preclinical research that utilizes nanotechnology to develop novel diagnostic imaging tools, translational models, and therapies to combat prostate cancer bone metastases.
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spelling pubmed-78284572021-01-25 Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis Hagaman, Daniel E. Damasco, Jossana A. Perez, Joy Vanessa D. Rojo, Raniv D. Melancon, Marites P. Molecules Review Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed. Nanotechnology is a versatile platform that has been used to increase the specificity and therapeutic efficacy of various treatments for prostate cancer bone metastases. In this review, we summarize preclinical research that utilizes nanotechnology to develop novel diagnostic imaging tools, translational models, and therapies to combat prostate cancer bone metastases. MDPI 2021-01-13 /pmc/articles/PMC7828457/ /pubmed/33450939 http://dx.doi.org/10.3390/molecules26020384 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hagaman, Daniel E.
Damasco, Jossana A.
Perez, Joy Vanessa D.
Rojo, Raniv D.
Melancon, Marites P.
Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis
title Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis
title_full Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis
title_fullStr Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis
title_full_unstemmed Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis
title_short Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis
title_sort recent advances in nanomedicine for the diagnosis and treatment of prostate cancer bone metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828457/
https://www.ncbi.nlm.nih.gov/pubmed/33450939
http://dx.doi.org/10.3390/molecules26020384
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