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Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis
Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828457/ https://www.ncbi.nlm.nih.gov/pubmed/33450939 http://dx.doi.org/10.3390/molecules26020384 |
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author | Hagaman, Daniel E. Damasco, Jossana A. Perez, Joy Vanessa D. Rojo, Raniv D. Melancon, Marites P. |
author_facet | Hagaman, Daniel E. Damasco, Jossana A. Perez, Joy Vanessa D. Rojo, Raniv D. Melancon, Marites P. |
author_sort | Hagaman, Daniel E. |
collection | PubMed |
description | Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed. Nanotechnology is a versatile platform that has been used to increase the specificity and therapeutic efficacy of various treatments for prostate cancer bone metastases. In this review, we summarize preclinical research that utilizes nanotechnology to develop novel diagnostic imaging tools, translational models, and therapies to combat prostate cancer bone metastases. |
format | Online Article Text |
id | pubmed-7828457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78284572021-01-25 Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis Hagaman, Daniel E. Damasco, Jossana A. Perez, Joy Vanessa D. Rojo, Raniv D. Melancon, Marites P. Molecules Review Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed. Nanotechnology is a versatile platform that has been used to increase the specificity and therapeutic efficacy of various treatments for prostate cancer bone metastases. In this review, we summarize preclinical research that utilizes nanotechnology to develop novel diagnostic imaging tools, translational models, and therapies to combat prostate cancer bone metastases. MDPI 2021-01-13 /pmc/articles/PMC7828457/ /pubmed/33450939 http://dx.doi.org/10.3390/molecules26020384 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hagaman, Daniel E. Damasco, Jossana A. Perez, Joy Vanessa D. Rojo, Raniv D. Melancon, Marites P. Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis |
title | Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis |
title_full | Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis |
title_fullStr | Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis |
title_full_unstemmed | Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis |
title_short | Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis |
title_sort | recent advances in nanomedicine for the diagnosis and treatment of prostate cancer bone metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828457/ https://www.ncbi.nlm.nih.gov/pubmed/33450939 http://dx.doi.org/10.3390/molecules26020384 |
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