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Phosphodiesterase Type-5 Inhibitor Tadalafil Modulates Steroid Hormones Signaling in a Prostate Cancer Cell Line

Background: The androgen receptor (AR) plays a key role in normal prostate homeostasis and in prostate cancer (PCa) development, while the role of aromatase (Cyp19a1) is still unclear. We evaluated the effects of a treatment with Tadalafil (TAD) on both these proteins. Methods: Androgen-sensitive hu...

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Detalles Bibliográficos
Autores principales:	Bimonte, Viviana M., Marampon, Francesco, Antonioni, Ambra, Fittipaldi, Simona, Ferretti, Elisabetta, Pestell, Richard G., Curreli, Mariaignazia, Lenzi, Andrea, Vitale, Giovanni, Brunetti, Antonio, Migliaccio, Silvia, Aversa, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828628/ https://www.ncbi.nlm.nih.gov/pubmed/33451122 http://dx.doi.org/10.3390/ijms22020754

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