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Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study

The blood–brain barrier (BBB) is equipped with unique physical and functional processes that control central nervous system (CNS) drug transport and the resulting concentration–time profiles (PK). In CNS diseases, the altered BBB and CNS pathophysiology may affect the CNS PK at the drug target sites...

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Detalles Bibliográficos
Autores principales:	Saleh, Mohammed A. A., de Lange, Elizabeth C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828633/ https://www.ncbi.nlm.nih.gov/pubmed/33451111 http://dx.doi.org/10.3390/pharmaceutics13010095

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