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Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [(177)Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model

1C1m-Fc, an anti-tumor endothelial marker 1 (TEM-1) scFv-Fc fusion protein antibody, was previously successfully radiolabeled with (177)Lu. TEM-1 specific tumor uptake was observed together with a non-saturation dependent liver uptake that could be related to the number of dodecane tetraacetic acid...

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Detalles Bibliográficos
Autores principales:	Delage, Judith Anna, Faivre-Chauvet, Alain, Barbet, Jacques, Fierle, Julie Katrin, Schaefer, Niklaus, Coukos, George, Viertl, David, Dunn, Steven Mark, Gnesin, Silvano, Prior, John O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828678/ https://www.ncbi.nlm.nih.gov/pubmed/33451158 http://dx.doi.org/10.3390/pharmaceutics13010096

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