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Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health
Several factors in Western society, including widespread use of antibiotics, chronic inflammation, and loss of complex eukaryotic symbionts such as helminths, have a dramatic impact on the ecosystem of the gut, affecting the microbiota hosted there. In addition, reductions in dietary fiber are profo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829112/ https://www.ncbi.nlm.nih.gov/pubmed/33552447 http://dx.doi.org/10.1016/j.csbj.2021.01.007 |
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author | Venkatakrishnan, Aarushi Holzknecht, Zoie E. Holzknecht, Rob Bowles, Dawn E. Kotzé, Sanet H. Modliszewski, Jennifer L. Parker, William |
author_facet | Venkatakrishnan, Aarushi Holzknecht, Zoie E. Holzknecht, Rob Bowles, Dawn E. Kotzé, Sanet H. Modliszewski, Jennifer L. Parker, William |
author_sort | Venkatakrishnan, Aarushi |
collection | PubMed |
description | Several factors in Western society, including widespread use of antibiotics, chronic inflammation, and loss of complex eukaryotic symbionts such as helminths, have a dramatic impact on the ecosystem of the gut, affecting the microbiota hosted there. In addition, reductions in dietary fiber are profoundly impactful on the microbiota, causing extensive destruction of the niche space that supports the normally diverse microbial community in the gut. Abundant evidence now supports the view that, following dramatic alterations in the gut ecosystem, microorganisms undergo rapid change via Darwinian evolution. Such evolutionary change creates functionally distinct bacteria that may potentially have properties of pathogens but yet are difficult to distinguish from their benign predecessors. |
format | Online Article Text |
id | pubmed-7829112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-78291122021-02-04 Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health Venkatakrishnan, Aarushi Holzknecht, Zoie E. Holzknecht, Rob Bowles, Dawn E. Kotzé, Sanet H. Modliszewski, Jennifer L. Parker, William Comput Struct Biotechnol J Review Article Several factors in Western society, including widespread use of antibiotics, chronic inflammation, and loss of complex eukaryotic symbionts such as helminths, have a dramatic impact on the ecosystem of the gut, affecting the microbiota hosted there. In addition, reductions in dietary fiber are profoundly impactful on the microbiota, causing extensive destruction of the niche space that supports the normally diverse microbial community in the gut. Abundant evidence now supports the view that, following dramatic alterations in the gut ecosystem, microorganisms undergo rapid change via Darwinian evolution. Such evolutionary change creates functionally distinct bacteria that may potentially have properties of pathogens but yet are difficult to distinguish from their benign predecessors. Research Network of Computational and Structural Biotechnology 2021-01-11 /pmc/articles/PMC7829112/ /pubmed/33552447 http://dx.doi.org/10.1016/j.csbj.2021.01.007 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Venkatakrishnan, Aarushi Holzknecht, Zoie E. Holzknecht, Rob Bowles, Dawn E. Kotzé, Sanet H. Modliszewski, Jennifer L. Parker, William Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health |
title | Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health |
title_full | Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health |
title_fullStr | Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health |
title_full_unstemmed | Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health |
title_short | Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health |
title_sort | evolution of bacteria in the human gut in response to changing environments: an invisible player in the game of health |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829112/ https://www.ncbi.nlm.nih.gov/pubmed/33552447 http://dx.doi.org/10.1016/j.csbj.2021.01.007 |
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