The p53/miR-145a Axis Promotes Cellular Senescence and Inhibits Osteogenic Differentiation by Targeting Cbfb in Mesenchymal Stem Cells

The osteogenic differentiation capacity of senescent bone marrow mesenchymal stem cells (MSCs) is reduced. p53 not only regulates cellular senescence but also functions as a negative regulator in bone formation. However, the role of p53 in MSCs senescence and differentiation has not been extensively...

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Detalles Bibliográficos
Autores principales: Xia, Chao, Jiang, Tianyuan, Wang, Yonghui, Chen, Xiaoting, Hu, Yan, Gao, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829338/
https://www.ncbi.nlm.nih.gov/pubmed/33505358
http://dx.doi.org/10.3389/fendo.2020.609186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829338/
https://www.ncbi.nlm.nih.gov/pubmed/33505358
http://dx.doi.org/10.3389/fendo.2020.609186

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