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Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents the absorption of liposaccharide (LPS). Structural changes to the intestinal epithelium in response to dietary alteration...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829348/ https://www.ncbi.nlm.nih.gov/pubmed/33505393 http://dx.doi.org/10.3389/fimmu.2020.594150 |
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author | Mohammad, Shireen Thiemermann, Christoph |
author_facet | Mohammad, Shireen Thiemermann, Christoph |
author_sort | Mohammad, Shireen |
collection | PubMed |
description | Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents the absorption of liposaccharide (LPS). Structural changes to the intestinal epithelium in response to dietary alterations allow LPS to enter the bloodstream, resulting in an increase in the plasma levels of LPS (termed metabolic endotoxemia). LPS activates Toll-like receptor-4 (TLR4) leading to the production of numerous pro-inflammatory cytokines and, hence, low-grade systemic inflammation. Thus, metabolic endotoxemia can lead to several chronic inflammatory conditions. Obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD) can also cause an increase in gut permeability and potential pharmacological and dietary interventions could be used to reduce the chronic low-grade inflammation associated with endotoxemia. |
format | Online Article Text |
id | pubmed-7829348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78293482021-01-26 Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions Mohammad, Shireen Thiemermann, Christoph Front Immunol Immunology Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents the absorption of liposaccharide (LPS). Structural changes to the intestinal epithelium in response to dietary alterations allow LPS to enter the bloodstream, resulting in an increase in the plasma levels of LPS (termed metabolic endotoxemia). LPS activates Toll-like receptor-4 (TLR4) leading to the production of numerous pro-inflammatory cytokines and, hence, low-grade systemic inflammation. Thus, metabolic endotoxemia can lead to several chronic inflammatory conditions. Obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD) can also cause an increase in gut permeability and potential pharmacological and dietary interventions could be used to reduce the chronic low-grade inflammation associated with endotoxemia. Frontiers Media S.A. 2021-01-11 /pmc/articles/PMC7829348/ /pubmed/33505393 http://dx.doi.org/10.3389/fimmu.2020.594150 Text en Copyright © 2021 Mohammad and Thiemermann http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Mohammad, Shireen Thiemermann, Christoph Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions |
title | Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions |
title_full | Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions |
title_fullStr | Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions |
title_full_unstemmed | Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions |
title_short | Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions |
title_sort | role of metabolic endotoxemia in systemic inflammation and potential interventions |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829348/ https://www.ncbi.nlm.nih.gov/pubmed/33505393 http://dx.doi.org/10.3389/fimmu.2020.594150 |
work_keys_str_mv | AT mohammadshireen roleofmetabolicendotoxemiainsystemicinflammationandpotentialinterventions AT thiemermannchristoph roleofmetabolicendotoxemiainsystemicinflammationandpotentialinterventions |