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Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry
Anxiety is a common comorbidity associated with chronic pain, which results in chronic pain complexification and difficulty in treatment. Electroacupuncture (EA) is commonly used to treat chronic pain and anxiety. However, the underlying mechanisms of the EA effect are largely unknown. Here, we show...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829552/ https://www.ncbi.nlm.nih.gov/pubmed/33505241 http://dx.doi.org/10.3389/fnins.2020.615395 |
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author | Shen, Zui Zhang, Haiyan Wu, Zemin He, Qiaoying Liu, Jinggen Xu, Yingling Yao, Shujing He, Xiaofen Chen, Yeqing Liang, Yi Liu, Boyi Jiang, Yongliang Fang, Junfan Du, Junying Zhu, Xixiao Wu, Mengwei Wu, Yuanyuan Sun, Jing Xu, Chi Fang, Jianqiao Shao, Xiaomei |
author_facet | Shen, Zui Zhang, Haiyan Wu, Zemin He, Qiaoying Liu, Jinggen Xu, Yingling Yao, Shujing He, Xiaofen Chen, Yeqing Liang, Yi Liu, Boyi Jiang, Yongliang Fang, Junfan Du, Junying Zhu, Xixiao Wu, Mengwei Wu, Yuanyuan Sun, Jing Xu, Chi Fang, Jianqiao Shao, Xiaomei |
author_sort | Shen, Zui |
collection | PubMed |
description | Anxiety is a common comorbidity associated with chronic pain, which results in chronic pain complexification and difficulty in treatment. Electroacupuncture (EA) is commonly used to treat chronic pain and anxiety. However, the underlying mechanisms of the EA effect are largely unknown. Here, we showed that a circuitry underlying chronic pain induces anxiety disorders, and EA can treat them by regulating such circuitry. Using chemogenetic methods, we found that chemogenetic activation of the rostral anterior cingulate cortex (rACC) glutamatergic output to the thalamus induced anxiety disorders in control rats. Then, chemogenetic inhibition of the rACC-thalamus circuitry reduced anxiety-like behavior produced by intraplantar injection of the complete Freund’s adjuvant (CFA). In this study, we examined the effects of EA on a rat model of CFA-mediated anxiety-like behaviors and the related mechanisms. We found that chemogenetic activation of the rACC-thalamus circuitry effectively blocked the effects of EA on chronic pain-induced anxiety-like behaviors in CFA rats. These results demonstrate an underlying rACC-thalamus glutamatergic circuitry that regulates CFA-mediated anxiety-like behaviors. This study also provides a potential mechanistic explanation for EA treatment of anxiety caused by chronic pain. |
format | Online Article Text |
id | pubmed-7829552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78295522021-01-26 Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry Shen, Zui Zhang, Haiyan Wu, Zemin He, Qiaoying Liu, Jinggen Xu, Yingling Yao, Shujing He, Xiaofen Chen, Yeqing Liang, Yi Liu, Boyi Jiang, Yongliang Fang, Junfan Du, Junying Zhu, Xixiao Wu, Mengwei Wu, Yuanyuan Sun, Jing Xu, Chi Fang, Jianqiao Shao, Xiaomei Front Neurosci Neuroscience Anxiety is a common comorbidity associated with chronic pain, which results in chronic pain complexification and difficulty in treatment. Electroacupuncture (EA) is commonly used to treat chronic pain and anxiety. However, the underlying mechanisms of the EA effect are largely unknown. Here, we showed that a circuitry underlying chronic pain induces anxiety disorders, and EA can treat them by regulating such circuitry. Using chemogenetic methods, we found that chemogenetic activation of the rostral anterior cingulate cortex (rACC) glutamatergic output to the thalamus induced anxiety disorders in control rats. Then, chemogenetic inhibition of the rACC-thalamus circuitry reduced anxiety-like behavior produced by intraplantar injection of the complete Freund’s adjuvant (CFA). In this study, we examined the effects of EA on a rat model of CFA-mediated anxiety-like behaviors and the related mechanisms. We found that chemogenetic activation of the rACC-thalamus circuitry effectively blocked the effects of EA on chronic pain-induced anxiety-like behaviors in CFA rats. These results demonstrate an underlying rACC-thalamus glutamatergic circuitry that regulates CFA-mediated anxiety-like behaviors. This study also provides a potential mechanistic explanation for EA treatment of anxiety caused by chronic pain. Frontiers Media S.A. 2021-01-11 /pmc/articles/PMC7829552/ /pubmed/33505241 http://dx.doi.org/10.3389/fnins.2020.615395 Text en Copyright © 2021 Shen, Zhang, Wu, He, Liu, Xu, Yao, He, Chen, Liang, Liu, Jiang, Fang, Du, Zhu, Wu, Wu, Sun, Xu, Fang and Shao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Shen, Zui Zhang, Haiyan Wu, Zemin He, Qiaoying Liu, Jinggen Xu, Yingling Yao, Shujing He, Xiaofen Chen, Yeqing Liang, Yi Liu, Boyi Jiang, Yongliang Fang, Junfan Du, Junying Zhu, Xixiao Wu, Mengwei Wu, Yuanyuan Sun, Jing Xu, Chi Fang, Jianqiao Shao, Xiaomei Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry |
title | Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry |
title_full | Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry |
title_fullStr | Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry |
title_full_unstemmed | Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry |
title_short | Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry |
title_sort | electroacupuncture alleviates chronic pain-induced anxiety disorders by regulating the racc-thalamus circuitry |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829552/ https://www.ncbi.nlm.nih.gov/pubmed/33505241 http://dx.doi.org/10.3389/fnins.2020.615395 |
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