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Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability

DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the nascent RNA strongly binds the template DNA strand, leading to the formation of a peculiar RNA–DNA hybr...

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Detalles Bibliográficos
Autores principales:	Rinaldi, Carlo, Pizzul, Paolo, Longhese, Maria Pia, Bonetti, Diego
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829580/ https://www.ncbi.nlm.nih.gov/pubmed/33505970 http://dx.doi.org/10.3389/fcell.2020.618157

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