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Solitary tibial lesion as the initial presentation of Langerhans cell histiocytosis: report of two cases and literature review
The various presentations of osseous Langerhans cell histiocytosis (LCH) make it difficult to distinguish from other bone diseases. In addition, there is no universally accepted protocol for managing osseous LCH for single non-central nervous system-risk lesions. Here, the rare cases of two paediatr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829610/ https://www.ncbi.nlm.nih.gov/pubmed/33472472 http://dx.doi.org/10.1177/0300060520982826 |
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author | Lin, Chih-Yang Lee, Chia-Che Wu, Kuan-Wen Yuan, Chang-Tsu Kuo, Ken-Nan Wang, Ting-Ming |
author_facet | Lin, Chih-Yang Lee, Chia-Che Wu, Kuan-Wen Yuan, Chang-Tsu Kuo, Ken-Nan Wang, Ting-Ming |
author_sort | Lin, Chih-Yang |
collection | PubMed |
description | The various presentations of osseous Langerhans cell histiocytosis (LCH) make it difficult to distinguish from other bone diseases. In addition, there is no universally accepted protocol for managing osseous LCH for single non-central nervous system-risk lesions. Here, the rare cases of two paediatric patients, aged 1 and 2 years, who presented with a solitary tibial lesion at time of LCH diagnosis, are reported. One patient progressed to multiple lesions after curettage of the original lesion. Subsequently, both patients received preventive chemotherapy using the Taiwan Paediatric Oncology Group (TPOG) revised protocol for treating low risk patients with LCH, namely, TPOG LCH2002-LR. After receiving this treatment, which included a schedule of prednisolone and vincristine for 6 weeks, followed by prednisolone, vincristine and 6-mercaptopurine for a further 48 weeks, both patients are free from recurrence or progression. |
format | Online Article Text |
id | pubmed-7829610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78296102021-02-05 Solitary tibial lesion as the initial presentation of Langerhans cell histiocytosis: report of two cases and literature review Lin, Chih-Yang Lee, Chia-Che Wu, Kuan-Wen Yuan, Chang-Tsu Kuo, Ken-Nan Wang, Ting-Ming J Int Med Res Case Report The various presentations of osseous Langerhans cell histiocytosis (LCH) make it difficult to distinguish from other bone diseases. In addition, there is no universally accepted protocol for managing osseous LCH for single non-central nervous system-risk lesions. Here, the rare cases of two paediatric patients, aged 1 and 2 years, who presented with a solitary tibial lesion at time of LCH diagnosis, are reported. One patient progressed to multiple lesions after curettage of the original lesion. Subsequently, both patients received preventive chemotherapy using the Taiwan Paediatric Oncology Group (TPOG) revised protocol for treating low risk patients with LCH, namely, TPOG LCH2002-LR. After receiving this treatment, which included a schedule of prednisolone and vincristine for 6 weeks, followed by prednisolone, vincristine and 6-mercaptopurine for a further 48 weeks, both patients are free from recurrence or progression. SAGE Publications 2021-01-20 /pmc/articles/PMC7829610/ /pubmed/33472472 http://dx.doi.org/10.1177/0300060520982826 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Lin, Chih-Yang Lee, Chia-Che Wu, Kuan-Wen Yuan, Chang-Tsu Kuo, Ken-Nan Wang, Ting-Ming Solitary tibial lesion as the initial presentation of Langerhans cell histiocytosis: report of two cases and literature review |
title | Solitary tibial lesion as the initial presentation of Langerhans cell
histiocytosis: report of two cases and literature review |
title_full | Solitary tibial lesion as the initial presentation of Langerhans cell
histiocytosis: report of two cases and literature review |
title_fullStr | Solitary tibial lesion as the initial presentation of Langerhans cell
histiocytosis: report of two cases and literature review |
title_full_unstemmed | Solitary tibial lesion as the initial presentation of Langerhans cell
histiocytosis: report of two cases and literature review |
title_short | Solitary tibial lesion as the initial presentation of Langerhans cell
histiocytosis: report of two cases and literature review |
title_sort | solitary tibial lesion as the initial presentation of langerhans cell
histiocytosis: report of two cases and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829610/ https://www.ncbi.nlm.nih.gov/pubmed/33472472 http://dx.doi.org/10.1177/0300060520982826 |
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