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Determinants of Phagosomal pH During Host-Pathogen Interactions
The ability of phagosomes to halt microbial growth is intimately linked to their ability to acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise co-ordination of H(+) pumping and counter-ion permeation to offset the countervailing H(+) leakage. Despite the best...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829662/ https://www.ncbi.nlm.nih.gov/pubmed/33505976 http://dx.doi.org/10.3389/fcell.2020.624958 |
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author | Westman, Johannes Grinstein, Sergio |
author_facet | Westman, Johannes Grinstein, Sergio |
author_sort | Westman, Johannes |
collection | PubMed |
description | The ability of phagosomes to halt microbial growth is intimately linked to their ability to acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise co-ordination of H(+) pumping and counter-ion permeation to offset the countervailing H(+) leakage. Despite the best efforts of professional phagocytes, however, a number of specialized pathogens survive and even replicate inside phagosomes. In such instances, pathogens target the pH-regulatory machinery of the host cell in an effort to survive inside or escape from phagosomes. This review aims to describe how phagosomal pH is regulated during phagocytosis, why it varies in different types of professional phagocytes and the strategies developed by prototypical intracellular pathogens to manipulate phagosomal pH to survive, replicate, and eventually escape from the phagocyte. |
format | Online Article Text |
id | pubmed-7829662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78296622021-01-26 Determinants of Phagosomal pH During Host-Pathogen Interactions Westman, Johannes Grinstein, Sergio Front Cell Dev Biol Cell and Developmental Biology The ability of phagosomes to halt microbial growth is intimately linked to their ability to acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise co-ordination of H(+) pumping and counter-ion permeation to offset the countervailing H(+) leakage. Despite the best efforts of professional phagocytes, however, a number of specialized pathogens survive and even replicate inside phagosomes. In such instances, pathogens target the pH-regulatory machinery of the host cell in an effort to survive inside or escape from phagosomes. This review aims to describe how phagosomal pH is regulated during phagocytosis, why it varies in different types of professional phagocytes and the strategies developed by prototypical intracellular pathogens to manipulate phagosomal pH to survive, replicate, and eventually escape from the phagocyte. Frontiers Media S.A. 2021-01-11 /pmc/articles/PMC7829662/ /pubmed/33505976 http://dx.doi.org/10.3389/fcell.2020.624958 Text en Copyright © 2021 Westman and Grinstein. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Westman, Johannes Grinstein, Sergio Determinants of Phagosomal pH During Host-Pathogen Interactions |
title | Determinants of Phagosomal pH During Host-Pathogen Interactions |
title_full | Determinants of Phagosomal pH During Host-Pathogen Interactions |
title_fullStr | Determinants of Phagosomal pH During Host-Pathogen Interactions |
title_full_unstemmed | Determinants of Phagosomal pH During Host-Pathogen Interactions |
title_short | Determinants of Phagosomal pH During Host-Pathogen Interactions |
title_sort | determinants of phagosomal ph during host-pathogen interactions |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829662/ https://www.ncbi.nlm.nih.gov/pubmed/33505976 http://dx.doi.org/10.3389/fcell.2020.624958 |
work_keys_str_mv | AT westmanjohannes determinantsofphagosomalphduringhostpathogeninteractions AT grinsteinsergio determinantsofphagosomalphduringhostpathogeninteractions |