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Regulation of Kv11.1 Isoform Expression by Polyadenylate Binding Protein Nuclear 1

The Kv11.1 voltage-gated potassium channel, encoded by the KCNH2 gene, conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative polyadenylation to generate two C-terminal Kv11.1 isoforms in the heart. Utilization of a poly(A) signal in exon 15 prod...

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Detalles Bibliográficos
Autores principales:	Stump, Matthew R., Nguyen, Rachel T., Drgastin, Rachel H., Search, Delaney, Gong, Qiuming, Zhou, Zhengfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829756/ https://www.ncbi.nlm.nih.gov/pubmed/33467093 http://dx.doi.org/10.3390/ijms22020863

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