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Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples

User-friendly, low-cost equipment for preventive screening of severe or deadly pathologies are one of the most sought devices by the National Health Services, as they allow early disease detection and treatment, often avoiding its degeneration. In recent years more and more research groups are devel...

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Autores principales: Astolfi, Michele, Rispoli, Giorgio, Anania, Gabriele, Artioli, Elena, Nevoso, Veronica, Zonta, Giulia, Malagù, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829789/
https://www.ncbi.nlm.nih.gov/pubmed/33477309
http://dx.doi.org/10.3390/molecules26020466
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author Astolfi, Michele
Rispoli, Giorgio
Anania, Gabriele
Artioli, Elena
Nevoso, Veronica
Zonta, Giulia
Malagù, Cesare
author_facet Astolfi, Michele
Rispoli, Giorgio
Anania, Gabriele
Artioli, Elena
Nevoso, Veronica
Zonta, Giulia
Malagù, Cesare
author_sort Astolfi, Michele
collection PubMed
description User-friendly, low-cost equipment for preventive screening of severe or deadly pathologies are one of the most sought devices by the National Health Services, as they allow early disease detection and treatment, often avoiding its degeneration. In recent years more and more research groups are developing devices aimed at these goals employing gas sensors. Here, nanostructured chemoresistive metal oxide (MOX) sensors were employed in a patented prototype aimed to detect volatile organic compounds (VOCs), exhaled by blood samples collected from patients affected by colorectal cancer and from healthy subjects as a control. Four sensors, carefully selected after many years of laboratory tests on biological samples (cultured cells, human stools, human biopsies, etc.), were based here on various percentages of tin, tungsten, titanium, niobium, tantalum and vanadium oxides. Sensor voltage responses were statistically analyzed also with the receiver operating characteristic (ROC) curves, that allowed the identification of the cut-off discriminating between healthy and tumor affected subjects for each sensor, leading to an estimate of sensitivity and specificity parameters. ROC analysis demonstrated that sensors employing tin and titanium oxides decorated with gold nanoparticles gave sensitivities up to 80% yet with a specificity of 70%.
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spelling pubmed-78297892021-01-26 Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples Astolfi, Michele Rispoli, Giorgio Anania, Gabriele Artioli, Elena Nevoso, Veronica Zonta, Giulia Malagù, Cesare Molecules Article User-friendly, low-cost equipment for preventive screening of severe or deadly pathologies are one of the most sought devices by the National Health Services, as they allow early disease detection and treatment, often avoiding its degeneration. In recent years more and more research groups are developing devices aimed at these goals employing gas sensors. Here, nanostructured chemoresistive metal oxide (MOX) sensors were employed in a patented prototype aimed to detect volatile organic compounds (VOCs), exhaled by blood samples collected from patients affected by colorectal cancer and from healthy subjects as a control. Four sensors, carefully selected after many years of laboratory tests on biological samples (cultured cells, human stools, human biopsies, etc.), were based here on various percentages of tin, tungsten, titanium, niobium, tantalum and vanadium oxides. Sensor voltage responses were statistically analyzed also with the receiver operating characteristic (ROC) curves, that allowed the identification of the cut-off discriminating between healthy and tumor affected subjects for each sensor, leading to an estimate of sensitivity and specificity parameters. ROC analysis demonstrated that sensors employing tin and titanium oxides decorated with gold nanoparticles gave sensitivities up to 80% yet with a specificity of 70%. MDPI 2021-01-17 /pmc/articles/PMC7829789/ /pubmed/33477309 http://dx.doi.org/10.3390/molecules26020466 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Astolfi, Michele
Rispoli, Giorgio
Anania, Gabriele
Artioli, Elena
Nevoso, Veronica
Zonta, Giulia
Malagù, Cesare
Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples
title Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples
title_full Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples
title_fullStr Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples
title_full_unstemmed Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples
title_short Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples
title_sort tin, titanium, tantalum, vanadium and niobium oxide based sensors to detect colorectal cancer exhalations in blood samples
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829789/
https://www.ncbi.nlm.nih.gov/pubmed/33477309
http://dx.doi.org/10.3390/molecules26020466
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