Endogenous Retroviruses in Nervous System Disorders

Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pa...

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Detalles Bibliográficos
Autores principales: Gröger, Victoria, Emmer, Alexander, Staege, Martin S., Cynis, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829834/
https://www.ncbi.nlm.nih.gov/pubmed/33467098
http://dx.doi.org/10.3390/ph14010070
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author Gröger, Victoria
Emmer, Alexander
Staege, Martin S.
Cynis, Holger
author_facet Gröger, Victoria
Emmer, Alexander
Staege, Martin S.
Cynis, Holger
author_sort Gröger, Victoria
collection PubMed
description Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.
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spelling pubmed-78298342021-01-26 Endogenous Retroviruses in Nervous System Disorders Gröger, Victoria Emmer, Alexander Staege, Martin S. Cynis, Holger Pharmaceuticals (Basel) Review Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies. MDPI 2021-01-16 /pmc/articles/PMC7829834/ /pubmed/33467098 http://dx.doi.org/10.3390/ph14010070 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gröger, Victoria
Emmer, Alexander
Staege, Martin S.
Cynis, Holger
Endogenous Retroviruses in Nervous System Disorders
title Endogenous Retroviruses in Nervous System Disorders
title_full Endogenous Retroviruses in Nervous System Disorders
title_fullStr Endogenous Retroviruses in Nervous System Disorders
title_full_unstemmed Endogenous Retroviruses in Nervous System Disorders
title_short Endogenous Retroviruses in Nervous System Disorders
title_sort endogenous retroviruses in nervous system disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829834/
https://www.ncbi.nlm.nih.gov/pubmed/33467098
http://dx.doi.org/10.3390/ph14010070
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