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Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection

Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. Methods: This sin...

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Autores principales: Belarte-Tornero, Laia C., Valdivielso-Moré, Sandra, Vicente Elcano, Miren, Solé-González, Eduard, Ruíz-Bustillo, Sonia, Calvo-Fernández, Alicia, Subinara, Isaac, Cabero, Paula, Soler, Cristina, Cubero-Gallego, Héctor, Vaquerizo, Beatriz, Farré, Núria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829899/
https://www.ncbi.nlm.nih.gov/pubmed/33477268
http://dx.doi.org/10.3390/jcm10020323
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author Belarte-Tornero, Laia C.
Valdivielso-Moré, Sandra
Vicente Elcano, Miren
Solé-González, Eduard
Ruíz-Bustillo, Sonia
Calvo-Fernández, Alicia
Subinara, Isaac
Cabero, Paula
Soler, Cristina
Cubero-Gallego, Héctor
Vaquerizo, Beatriz
Farré, Núria
author_facet Belarte-Tornero, Laia C.
Valdivielso-Moré, Sandra
Vicente Elcano, Miren
Solé-González, Eduard
Ruíz-Bustillo, Sonia
Calvo-Fernández, Alicia
Subinara, Isaac
Cabero, Paula
Soler, Cristina
Cubero-Gallego, Héctor
Vaquerizo, Beatriz
Farré, Núria
author_sort Belarte-Tornero, Laia C.
collection PubMed
description Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26–2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF. Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26–4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.
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spelling pubmed-78298992021-01-26 Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection Belarte-Tornero, Laia C. Valdivielso-Moré, Sandra Vicente Elcano, Miren Solé-González, Eduard Ruíz-Bustillo, Sonia Calvo-Fernández, Alicia Subinara, Isaac Cabero, Paula Soler, Cristina Cubero-Gallego, Héctor Vaquerizo, Beatriz Farré, Núria J Clin Med Article Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26–2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF. Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26–4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding. MDPI 2021-01-17 /pmc/articles/PMC7829899/ /pubmed/33477268 http://dx.doi.org/10.3390/jcm10020323 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Belarte-Tornero, Laia C.
Valdivielso-Moré, Sandra
Vicente Elcano, Miren
Solé-González, Eduard
Ruíz-Bustillo, Sonia
Calvo-Fernández, Alicia
Subinara, Isaac
Cabero, Paula
Soler, Cristina
Cubero-Gallego, Héctor
Vaquerizo, Beatriz
Farré, Núria
Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
title Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
title_full Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
title_fullStr Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
title_full_unstemmed Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
title_short Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
title_sort prognostic implications of chronic heart failure and utility of nt-probnp levels in heart failure patients with sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829899/
https://www.ncbi.nlm.nih.gov/pubmed/33477268
http://dx.doi.org/10.3390/jcm10020323
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