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The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance
SIMPLE SUMMARY: Based on the four molecular subtypes of pancreatic cancer described by Bailey et al. 2016, in the present article we match the molecular, histology and microenvironment features of pancreatic cancer. This approach may help to understand the molecular basis of this kind of tumor, and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829908/ https://www.ncbi.nlm.nih.gov/pubmed/33477288 http://dx.doi.org/10.3390/cancers13020322 |
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author | Martinez-Useros, Javier Martin-Galan, Mario Garcia-Foncillas, Jesus |
author_facet | Martinez-Useros, Javier Martin-Galan, Mario Garcia-Foncillas, Jesus |
author_sort | Martinez-Useros, Javier |
collection | PubMed |
description | SIMPLE SUMMARY: Based on the four molecular subtypes of pancreatic cancer described by Bailey et al. 2016, in the present article we match the molecular, histology and microenvironment features of pancreatic cancer. This approach may help to understand the molecular basis of this kind of tumor, and how their microenvironment may affect treatment response. Moreover, we compile information about crucial factors that could serve as potential targets for drug design to achieve higher anti-tumor activity, and how histological evaluation of tumor microenvironment could provide first signs about treatment response. ABSTRACT: In the last decade, several studies based on whole transcriptomic and genomic analyses of pancreatic tumors and their stroma have come to light to supplement histopathological stratification of pancreatic cancers with a molecular point-of-view. Three main molecular studies: Collisson et al. 2011, Moffitt et al. 2015 and Bailey et al. 2016 have found specific gene signatures, which identify different molecular subtypes of pancreatic cancer and provide a comprehensive stratification for both a personalized treatment or to identify potential druggable targets. However, the routine clinical management of pancreatic cancer does not consider a broad molecular analysis of each patient, due probably to the lack of target therapies for this tumor. Therefore, the current treatment decision is taken based on patients´ clinicopathological features and performance status. Histopathological evaluation of tumor samples could reveal many other attributes not only from tumor cells but also from their microenvironment specially about the presence of pancreatic stellate cells, regulatory T cells, tumor-associated macrophages, myeloid derived suppressor cells and extracellular matrix structure. In the present article, we revise the four molecular subtypes proposed by Bailey et al. and associate each subtype with other reported molecular subtypes. Moreover, we provide for each subtype a potential description of the tumor microenvironment that may influence treatment response according to the gene expression profile, the mutational landscape and their associated histology. |
format | Online Article Text |
id | pubmed-7829908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78299082021-01-26 The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance Martinez-Useros, Javier Martin-Galan, Mario Garcia-Foncillas, Jesus Cancers (Basel) Review SIMPLE SUMMARY: Based on the four molecular subtypes of pancreatic cancer described by Bailey et al. 2016, in the present article we match the molecular, histology and microenvironment features of pancreatic cancer. This approach may help to understand the molecular basis of this kind of tumor, and how their microenvironment may affect treatment response. Moreover, we compile information about crucial factors that could serve as potential targets for drug design to achieve higher anti-tumor activity, and how histological evaluation of tumor microenvironment could provide first signs about treatment response. ABSTRACT: In the last decade, several studies based on whole transcriptomic and genomic analyses of pancreatic tumors and their stroma have come to light to supplement histopathological stratification of pancreatic cancers with a molecular point-of-view. Three main molecular studies: Collisson et al. 2011, Moffitt et al. 2015 and Bailey et al. 2016 have found specific gene signatures, which identify different molecular subtypes of pancreatic cancer and provide a comprehensive stratification for both a personalized treatment or to identify potential druggable targets. However, the routine clinical management of pancreatic cancer does not consider a broad molecular analysis of each patient, due probably to the lack of target therapies for this tumor. Therefore, the current treatment decision is taken based on patients´ clinicopathological features and performance status. Histopathological evaluation of tumor samples could reveal many other attributes not only from tumor cells but also from their microenvironment specially about the presence of pancreatic stellate cells, regulatory T cells, tumor-associated macrophages, myeloid derived suppressor cells and extracellular matrix structure. In the present article, we revise the four molecular subtypes proposed by Bailey et al. and associate each subtype with other reported molecular subtypes. Moreover, we provide for each subtype a potential description of the tumor microenvironment that may influence treatment response according to the gene expression profile, the mutational landscape and their associated histology. MDPI 2021-01-17 /pmc/articles/PMC7829908/ /pubmed/33477288 http://dx.doi.org/10.3390/cancers13020322 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martinez-Useros, Javier Martin-Galan, Mario Garcia-Foncillas, Jesus The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance |
title | The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance |
title_full | The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance |
title_fullStr | The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance |
title_full_unstemmed | The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance |
title_short | The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance |
title_sort | match between molecular subtypes, histology and microenvironment of pancreatic cancer and its relevance for chemoresistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829908/ https://www.ncbi.nlm.nih.gov/pubmed/33477288 http://dx.doi.org/10.3390/cancers13020322 |
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