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Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study

Despite intensive lipid-lowering interventions, patients treated with statins develop atherosclerotic cardiovascular disease (ASCVD), and these patients have an increased risk of developing recurrent cardiovascular events during follow-up. Therefore, there is a need to focus on the residual risks in...

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Autores principales: Okada, Tomoaki, Miyoshi, Toru, Doi, Masayuki, Seiyama, Kosuke, Takagi, Wataru, Sogo, Masahiro, Nosaka, Kazumasa, Takahashi, Masahiko, Okawa, Keisuke, Ito, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829914/
https://www.ncbi.nlm.nih.gov/pubmed/33477264
http://dx.doi.org/10.3390/nu13010253
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author Okada, Tomoaki
Miyoshi, Toru
Doi, Masayuki
Seiyama, Kosuke
Takagi, Wataru
Sogo, Masahiro
Nosaka, Kazumasa
Takahashi, Masahiko
Okawa, Keisuke
Ito, Hiroshi
author_facet Okada, Tomoaki
Miyoshi, Toru
Doi, Masayuki
Seiyama, Kosuke
Takagi, Wataru
Sogo, Masahiro
Nosaka, Kazumasa
Takahashi, Masahiko
Okawa, Keisuke
Ito, Hiroshi
author_sort Okada, Tomoaki
collection PubMed
description Despite intensive lipid-lowering interventions, patients treated with statins develop atherosclerotic cardiovascular disease (ASCVD), and these patients have an increased risk of developing recurrent cardiovascular events during follow-up. Therefore, there is a need to focus on the residual risks in patients in statin therapy to further reduce ASCVD. The aim of this study was to retrospectively investigate the 10-year trend (2011–2019) regarding changes in polyunsaturated fatty acids (PUFAs) in patients with acute coronary syndrome (ACS) in a single center. We included 686 men and 203 women with ACS admitted to Kagawa Prefectural Central Hospital. Plasma PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-γ-linolenic acid (DGLA), were measured at admission for suspected ACS. A secular decreasing trend in the levels of EPA and DHA and the EPA/AA ratio, but not of AA and DGLA, was observed. The analyses based on age (>70 or <70 years) and sex showed that the decreasing trend in the levels of EPA and DHA did not depend on age and remained significant only in men. Further studies are needed to obtain robust evidence to justify that the administration of n-3 PUFA contributes to the secondary prevention of ACS.
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spelling pubmed-78299142021-01-26 Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study Okada, Tomoaki Miyoshi, Toru Doi, Masayuki Seiyama, Kosuke Takagi, Wataru Sogo, Masahiro Nosaka, Kazumasa Takahashi, Masahiko Okawa, Keisuke Ito, Hiroshi Nutrients Article Despite intensive lipid-lowering interventions, patients treated with statins develop atherosclerotic cardiovascular disease (ASCVD), and these patients have an increased risk of developing recurrent cardiovascular events during follow-up. Therefore, there is a need to focus on the residual risks in patients in statin therapy to further reduce ASCVD. The aim of this study was to retrospectively investigate the 10-year trend (2011–2019) regarding changes in polyunsaturated fatty acids (PUFAs) in patients with acute coronary syndrome (ACS) in a single center. We included 686 men and 203 women with ACS admitted to Kagawa Prefectural Central Hospital. Plasma PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-γ-linolenic acid (DGLA), were measured at admission for suspected ACS. A secular decreasing trend in the levels of EPA and DHA and the EPA/AA ratio, but not of AA and DGLA, was observed. The analyses based on age (>70 or <70 years) and sex showed that the decreasing trend in the levels of EPA and DHA did not depend on age and remained significant only in men. Further studies are needed to obtain robust evidence to justify that the administration of n-3 PUFA contributes to the secondary prevention of ACS. MDPI 2021-01-17 /pmc/articles/PMC7829914/ /pubmed/33477264 http://dx.doi.org/10.3390/nu13010253 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Okada, Tomoaki
Miyoshi, Toru
Doi, Masayuki
Seiyama, Kosuke
Takagi, Wataru
Sogo, Masahiro
Nosaka, Kazumasa
Takahashi, Masahiko
Okawa, Keisuke
Ito, Hiroshi
Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study
title Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study
title_full Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study
title_fullStr Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study
title_full_unstemmed Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study
title_short Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study
title_sort secular decreasing trend in plasma eicosapentaenoic and docosahexaenoic acids among patients with acute coronary syndrome from 2011 to 2019: a single center descriptive study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829914/
https://www.ncbi.nlm.nih.gov/pubmed/33477264
http://dx.doi.org/10.3390/nu13010253
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