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Cellular Receptors Involved in KSHV Infection

The process of Kaposi’s Sarcoma Herpes Virus’ (KSHV) entry into target cells is complex and engages several viral glycoproteins which bind to a large range of host cell surface molecules. Receptors for KSHV include heparan sulphate proteoglycans (HSPGs), several integrins and Eph receptors, cystine/...

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Detalles Bibliográficos
Autores principales: van der Meulen, Emma, Anderton, Meg, Blumenthal, Melissa J., Schäfer, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829929/
https://www.ncbi.nlm.nih.gov/pubmed/33477296
http://dx.doi.org/10.3390/v13010118
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author van der Meulen, Emma
Anderton, Meg
Blumenthal, Melissa J.
Schäfer, Georgia
author_facet van der Meulen, Emma
Anderton, Meg
Blumenthal, Melissa J.
Schäfer, Georgia
author_sort van der Meulen, Emma
collection PubMed
description The process of Kaposi’s Sarcoma Herpes Virus’ (KSHV) entry into target cells is complex and engages several viral glycoproteins which bind to a large range of host cell surface molecules. Receptors for KSHV include heparan sulphate proteoglycans (HSPGs), several integrins and Eph receptors, cystine/glutamate antiporter (xCT) and Dendritic Cell-Specific Intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN). This diverse range of potential binding and entry sites allows KSHV to have a broad cell tropism, and entry into specific cells is dependent on the available receptor repertoire. Several molecules involved in KSHV entry have been well characterized, particularly those postulated to be associated with KSHV-associated pathologies such as Kaposi’s Sarcoma (KS). In this review, KSHV infection of specific cell types pertinent to its pathogenesis will be comprehensively summarized with a focus on the specific cell surface binding and entry receptors KSHV exploits to gain access to a variety of cell types. Gaps in the current literature regarding understanding interactions between KSHV glycoproteins and cellular receptors in virus infection are identified which will lead to the development of virus infection intervention strategies.
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spelling pubmed-78299292021-01-26 Cellular Receptors Involved in KSHV Infection van der Meulen, Emma Anderton, Meg Blumenthal, Melissa J. Schäfer, Georgia Viruses Review The process of Kaposi’s Sarcoma Herpes Virus’ (KSHV) entry into target cells is complex and engages several viral glycoproteins which bind to a large range of host cell surface molecules. Receptors for KSHV include heparan sulphate proteoglycans (HSPGs), several integrins and Eph receptors, cystine/glutamate antiporter (xCT) and Dendritic Cell-Specific Intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN). This diverse range of potential binding and entry sites allows KSHV to have a broad cell tropism, and entry into specific cells is dependent on the available receptor repertoire. Several molecules involved in KSHV entry have been well characterized, particularly those postulated to be associated with KSHV-associated pathologies such as Kaposi’s Sarcoma (KS). In this review, KSHV infection of specific cell types pertinent to its pathogenesis will be comprehensively summarized with a focus on the specific cell surface binding and entry receptors KSHV exploits to gain access to a variety of cell types. Gaps in the current literature regarding understanding interactions between KSHV glycoproteins and cellular receptors in virus infection are identified which will lead to the development of virus infection intervention strategies. MDPI 2021-01-17 /pmc/articles/PMC7829929/ /pubmed/33477296 http://dx.doi.org/10.3390/v13010118 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van der Meulen, Emma
Anderton, Meg
Blumenthal, Melissa J.
Schäfer, Georgia
Cellular Receptors Involved in KSHV Infection
title Cellular Receptors Involved in KSHV Infection
title_full Cellular Receptors Involved in KSHV Infection
title_fullStr Cellular Receptors Involved in KSHV Infection
title_full_unstemmed Cellular Receptors Involved in KSHV Infection
title_short Cellular Receptors Involved in KSHV Infection
title_sort cellular receptors involved in kshv infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829929/
https://www.ncbi.nlm.nih.gov/pubmed/33477296
http://dx.doi.org/10.3390/v13010118
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