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Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis

Despite the considerable number of studies investigating the Mediterranean diet in prostate cancer (PCa) etiology, very few focused on cancer survival. We assessed the pre-diagnostic diet and physical activity in a cohort of 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy; ad...

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Autores principales: Di Maso, Matteo, Augustin, Livia S. A., Toffolutti, Federica, Stocco, Carmen, Dal Maso, Luigino, Jenkins, David J. A., Fleshner, Neil E., Serraino, Diego, Polesel, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829941/
https://www.ncbi.nlm.nih.gov/pubmed/33467042
http://dx.doi.org/10.3390/nu13010243
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author Di Maso, Matteo
Augustin, Livia S. A.
Toffolutti, Federica
Stocco, Carmen
Dal Maso, Luigino
Jenkins, David J. A.
Fleshner, Neil E.
Serraino, Diego
Polesel, Jerry
author_facet Di Maso, Matteo
Augustin, Livia S. A.
Toffolutti, Federica
Stocco, Carmen
Dal Maso, Luigino
Jenkins, David J. A.
Fleshner, Neil E.
Serraino, Diego
Polesel, Jerry
author_sort Di Maso, Matteo
collection PubMed
description Despite the considerable number of studies investigating the Mediterranean diet in prostate cancer (PCa) etiology, very few focused on cancer survival. We assessed the pre-diagnostic diet and physical activity in a cohort of 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy; adherence to the Mediterranean diet was evaluated through the Mediterranean Diet Score (MDS). Hazard ratios (HR) of death with confidence intervals (CI) were estimated using the Cox model, adjusting for potential confounders. During 10 years of follow-up, 208 patients (26.8%) died, 75 (9.7%) due to PCa. Patients reporting MDS ≥ 5 showed a higher overall survival than those with MDS < 5 (HR = 0.74; 95% CI: 0.56–0.99). Although high physical activity was not significantly associated with overall survival (HR = 0.79; 95% CI: 0.59–1.07), the HR for all-cause death was the lowest (HR = 0.58; 95% CI: 0.38–0.90) for men reporting MDS ≥ 5 and high physical activity compared to those reporting MDS < 5 and low/moderate physical activity. No association emerged for PCa specific survival. Study findings support the beneficial impact of pre-diagnostic adherence to the Mediterranean diet and physical activity on overall survival; they are mainly driven by risk reduction in non-prostate cancer mortality, which however accounts for about 80% of death in men with PCa.
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spelling pubmed-78299412021-01-26 Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis Di Maso, Matteo Augustin, Livia S. A. Toffolutti, Federica Stocco, Carmen Dal Maso, Luigino Jenkins, David J. A. Fleshner, Neil E. Serraino, Diego Polesel, Jerry Nutrients Article Despite the considerable number of studies investigating the Mediterranean diet in prostate cancer (PCa) etiology, very few focused on cancer survival. We assessed the pre-diagnostic diet and physical activity in a cohort of 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy; adherence to the Mediterranean diet was evaluated through the Mediterranean Diet Score (MDS). Hazard ratios (HR) of death with confidence intervals (CI) were estimated using the Cox model, adjusting for potential confounders. During 10 years of follow-up, 208 patients (26.8%) died, 75 (9.7%) due to PCa. Patients reporting MDS ≥ 5 showed a higher overall survival than those with MDS < 5 (HR = 0.74; 95% CI: 0.56–0.99). Although high physical activity was not significantly associated with overall survival (HR = 0.79; 95% CI: 0.59–1.07), the HR for all-cause death was the lowest (HR = 0.58; 95% CI: 0.38–0.90) for men reporting MDS ≥ 5 and high physical activity compared to those reporting MDS < 5 and low/moderate physical activity. No association emerged for PCa specific survival. Study findings support the beneficial impact of pre-diagnostic adherence to the Mediterranean diet and physical activity on overall survival; they are mainly driven by risk reduction in non-prostate cancer mortality, which however accounts for about 80% of death in men with PCa. MDPI 2021-01-16 /pmc/articles/PMC7829941/ /pubmed/33467042 http://dx.doi.org/10.3390/nu13010243 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Di Maso, Matteo
Augustin, Livia S. A.
Toffolutti, Federica
Stocco, Carmen
Dal Maso, Luigino
Jenkins, David J. A.
Fleshner, Neil E.
Serraino, Diego
Polesel, Jerry
Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis
title Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis
title_full Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis
title_fullStr Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis
title_full_unstemmed Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis
title_short Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis
title_sort adherence to mediterranean diet, physical activity and survival after prostate cancer diagnosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829941/
https://www.ncbi.nlm.nih.gov/pubmed/33467042
http://dx.doi.org/10.3390/nu13010243
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