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Loss of Social/Non-social Context Discrimination by Movement Acceleration in the Valproate Model of Autism

Autism spectrum disorder (ASD) is a neurodevelopmental alteration characterized by social/communicative deficits, repetitive/stereotyped movements, and restricted/obsessive interests. However, there is not much information about whether movement alterations in ASD comprise modifications at the basic...

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Autores principales: Quezada, Nelva T., Salas-Ortíz, Sebastiana F., Peralta, Francisco A., Aguayo, Felipe I., Morgado-Gallardo, Katherine P., Mac-Rae, Catherine A., Fiedler, Jenny L., Aliaga, Esteban E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829965/
https://www.ncbi.nlm.nih.gov/pubmed/33505254
http://dx.doi.org/10.3389/fnbeh.2020.555610
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author Quezada, Nelva T.
Salas-Ortíz, Sebastiana F.
Peralta, Francisco A.
Aguayo, Felipe I.
Morgado-Gallardo, Katherine P.
Mac-Rae, Catherine A.
Fiedler, Jenny L.
Aliaga, Esteban E.
author_facet Quezada, Nelva T.
Salas-Ortíz, Sebastiana F.
Peralta, Francisco A.
Aguayo, Felipe I.
Morgado-Gallardo, Katherine P.
Mac-Rae, Catherine A.
Fiedler, Jenny L.
Aliaga, Esteban E.
author_sort Quezada, Nelva T.
collection PubMed
description Autism spectrum disorder (ASD) is a neurodevelopmental alteration characterized by social/communicative deficits, repetitive/stereotyped movements, and restricted/obsessive interests. However, there is not much information about whether movement alterations in ASD comprise modifications at the basic kinematic level, such as trajectory and velocity, which may contribute to the higher level of processing that allows the perception and interpretation of actions performed by others, and hence, impact social interaction. In order to further explore possible motor alterations in ASD, we analyzed movement parameters in the Valproate (VPA) animal model of autism. We found that VPA-treated rats displayed greater movement acceleration, reduced distance between stops, spent more time in the corner of the open-field arena, and executed a number of particular behaviors; for example, supported rearing and circling, with no major changes in distance and velocity. However, in the social interaction test, we found other alterations in the movement parameters. In addition to increased acceleration, VPA-rats displayed reduced velocity, increased stops, reduced distance/stop and lost the social/non-social area discrimination that is characteristic of control rats in acceleration and stops variables. Hence, even if prenatal VPA-treatment could have a minor effect in motor variables in a non-social context, it has a crucial effect in the capacity of the animals to adjust their kinematic variables when social/non-social context alternation is required.
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spelling pubmed-78299652021-01-26 Loss of Social/Non-social Context Discrimination by Movement Acceleration in the Valproate Model of Autism Quezada, Nelva T. Salas-Ortíz, Sebastiana F. Peralta, Francisco A. Aguayo, Felipe I. Morgado-Gallardo, Katherine P. Mac-Rae, Catherine A. Fiedler, Jenny L. Aliaga, Esteban E. Front Behav Neurosci Neuroscience Autism spectrum disorder (ASD) is a neurodevelopmental alteration characterized by social/communicative deficits, repetitive/stereotyped movements, and restricted/obsessive interests. However, there is not much information about whether movement alterations in ASD comprise modifications at the basic kinematic level, such as trajectory and velocity, which may contribute to the higher level of processing that allows the perception and interpretation of actions performed by others, and hence, impact social interaction. In order to further explore possible motor alterations in ASD, we analyzed movement parameters in the Valproate (VPA) animal model of autism. We found that VPA-treated rats displayed greater movement acceleration, reduced distance between stops, spent more time in the corner of the open-field arena, and executed a number of particular behaviors; for example, supported rearing and circling, with no major changes in distance and velocity. However, in the social interaction test, we found other alterations in the movement parameters. In addition to increased acceleration, VPA-rats displayed reduced velocity, increased stops, reduced distance/stop and lost the social/non-social area discrimination that is characteristic of control rats in acceleration and stops variables. Hence, even if prenatal VPA-treatment could have a minor effect in motor variables in a non-social context, it has a crucial effect in the capacity of the animals to adjust their kinematic variables when social/non-social context alternation is required. Frontiers Media S.A. 2021-01-11 /pmc/articles/PMC7829965/ /pubmed/33505254 http://dx.doi.org/10.3389/fnbeh.2020.555610 Text en Copyright © 2021 Quezada, Salas-Ortíz, Peralta, Aguayo, Morgado-Gallardo, Mac-Rae, Fiedler and Aliaga. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Quezada, Nelva T.
Salas-Ortíz, Sebastiana F.
Peralta, Francisco A.
Aguayo, Felipe I.
Morgado-Gallardo, Katherine P.
Mac-Rae, Catherine A.
Fiedler, Jenny L.
Aliaga, Esteban E.
Loss of Social/Non-social Context Discrimination by Movement Acceleration in the Valproate Model of Autism
title Loss of Social/Non-social Context Discrimination by Movement Acceleration in the Valproate Model of Autism
title_full Loss of Social/Non-social Context Discrimination by Movement Acceleration in the Valproate Model of Autism
title_fullStr Loss of Social/Non-social Context Discrimination by Movement Acceleration in the Valproate Model of Autism
title_full_unstemmed Loss of Social/Non-social Context Discrimination by Movement Acceleration in the Valproate Model of Autism
title_short Loss of Social/Non-social Context Discrimination by Movement Acceleration in the Valproate Model of Autism
title_sort loss of social/non-social context discrimination by movement acceleration in the valproate model of autism
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829965/
https://www.ncbi.nlm.nih.gov/pubmed/33505254
http://dx.doi.org/10.3389/fnbeh.2020.555610
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