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Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay
Intimate metabolic host–microbiome crosstalk regulates immune, metabolic, and neuronal response in health and disease, yet remains untapped for biomarkers or intervention for disease. Our recent study identified an altered microbiome in patients with pre-onset amnestic mild cognitive impairment (aMC...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829997/ https://www.ncbi.nlm.nih.gov/pubmed/33466861 http://dx.doi.org/10.3390/nu13010228 |
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author | Wu, Li Han, Yuqiu Zheng, Zhipeng Peng, Guoping Liu, Ping Yue, Siqing Zhu, Shuai Chen, Jun Lv, Hanying Shao, Lifang Sheng, Yan Wang, Yulan Li, Liang Li, Lanjuan Wang, Baohong |
author_facet | Wu, Li Han, Yuqiu Zheng, Zhipeng Peng, Guoping Liu, Ping Yue, Siqing Zhu, Shuai Chen, Jun Lv, Hanying Shao, Lifang Sheng, Yan Wang, Yulan Li, Liang Li, Lanjuan Wang, Baohong |
author_sort | Wu, Li |
collection | PubMed |
description | Intimate metabolic host–microbiome crosstalk regulates immune, metabolic, and neuronal response in health and disease, yet remains untapped for biomarkers or intervention for disease. Our recent study identified an altered microbiome in patients with pre-onset amnestic mild cognitive impairment (aMCI) and dementia Alzheimer’s disease (AD). Thus, we aimed to characterize the gut microbial metabolites among AD, aMCI, and healthy controls (HC). Here, a cohort of 77 individuals (22 aMCI, 27 AD, and 28 HC) was recruited. With the use of liquid-chromatography/gas chromatography mass spectrometry metabolomics profiling, we identified significant differences between AD and HC for tryptophan metabolites, short-chain fatty acids (SCFAs), and lithocholic acid, the majority of which correlated with altered microbiota and cognitive impairment. Notably, tryptophan disorders presented in aMCI and SCFAs decreased progressively from aMCI to AD. Importantly, indole-3-pyruvic acid, a metabolite from tryptophan, was identified as a signature for discrimination and prediction of AD, and five SCFAs for pre-onset and progression of AD. This study showed fecal-based gut microbial signatures were associated with the presence and progression of AD, providing a potential target for microbiota or dietary intervention in AD prevention and support for the host–microbe crosstalk signals in AD pathophysiology. |
format | Online Article Text |
id | pubmed-7829997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78299972021-01-26 Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay Wu, Li Han, Yuqiu Zheng, Zhipeng Peng, Guoping Liu, Ping Yue, Siqing Zhu, Shuai Chen, Jun Lv, Hanying Shao, Lifang Sheng, Yan Wang, Yulan Li, Liang Li, Lanjuan Wang, Baohong Nutrients Article Intimate metabolic host–microbiome crosstalk regulates immune, metabolic, and neuronal response in health and disease, yet remains untapped for biomarkers or intervention for disease. Our recent study identified an altered microbiome in patients with pre-onset amnestic mild cognitive impairment (aMCI) and dementia Alzheimer’s disease (AD). Thus, we aimed to characterize the gut microbial metabolites among AD, aMCI, and healthy controls (HC). Here, a cohort of 77 individuals (22 aMCI, 27 AD, and 28 HC) was recruited. With the use of liquid-chromatography/gas chromatography mass spectrometry metabolomics profiling, we identified significant differences between AD and HC for tryptophan metabolites, short-chain fatty acids (SCFAs), and lithocholic acid, the majority of which correlated with altered microbiota and cognitive impairment. Notably, tryptophan disorders presented in aMCI and SCFAs decreased progressively from aMCI to AD. Importantly, indole-3-pyruvic acid, a metabolite from tryptophan, was identified as a signature for discrimination and prediction of AD, and five SCFAs for pre-onset and progression of AD. This study showed fecal-based gut microbial signatures were associated with the presence and progression of AD, providing a potential target for microbiota or dietary intervention in AD prevention and support for the host–microbe crosstalk signals in AD pathophysiology. MDPI 2021-01-14 /pmc/articles/PMC7829997/ /pubmed/33466861 http://dx.doi.org/10.3390/nu13010228 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wu, Li Han, Yuqiu Zheng, Zhipeng Peng, Guoping Liu, Ping Yue, Siqing Zhu, Shuai Chen, Jun Lv, Hanying Shao, Lifang Sheng, Yan Wang, Yulan Li, Liang Li, Lanjuan Wang, Baohong Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay |
title | Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay |
title_full | Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay |
title_fullStr | Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay |
title_full_unstemmed | Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay |
title_short | Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay |
title_sort | altered gut microbial metabolites in amnestic mild cognitive impairment and alzheimer’s disease: signals in host–microbe interplay |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829997/ https://www.ncbi.nlm.nih.gov/pubmed/33466861 http://dx.doi.org/10.3390/nu13010228 |
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