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Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer
SIMPLE SUMMARY: A subset of colorectal cancers (CRCs) displays deficient DNA mismatch repair (dMMR) that leads to microsatellite instability (MSI). These tumors have distinct clinicopathological features and have been associated with a more favorable prognosis. Knowledge of mismatch repair (MMR) sta...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830023/ https://www.ncbi.nlm.nih.gov/pubmed/33467526 http://dx.doi.org/10.3390/cancers13020300 |
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author | Jin, Zhaohui Sinicrope, Frank A. |
author_facet | Jin, Zhaohui Sinicrope, Frank A. |
author_sort | Jin, Zhaohui |
collection | PubMed |
description | SIMPLE SUMMARY: A subset of colorectal cancers (CRCs) displays deficient DNA mismatch repair (dMMR) that leads to microsatellite instability (MSI). These tumors have distinct clinicopathological features and have been associated with a more favorable prognosis. Knowledge of mismatch repair (MMR) status has important implications for disease diagnosis, surgical intervention, and adjuvant treatment decisions. ABSTRACT: Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Universal MMR/MSI testing is standard of care for all patients with newly diagnosed CRC based on multi-society guidelines in the United States. Such testing is intended to identify patients with Lynch Syndrome due to a germline mutation in an MMR gene, but also detects those with sporadic dMMR/MSI-high CRCs. The prognostic utility of MMR/MSI status in non-metastatic colorectal cancer has been studied extensively, yet more limited data are available for its predictive utility. Results have not been entirely consistent due to potential stage-related differences and limited numbers of dMMR/MSI-H patients included in the studies. In this review, we summarize the current evidence for the prognostic and predictive value of dMMR/MSI-H in non-metastatic CRC, and discuss the use of this biomarker for patient management and treatment decisions in clinical practice. |
format | Online Article Text |
id | pubmed-7830023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78300232021-01-26 Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer Jin, Zhaohui Sinicrope, Frank A. Cancers (Basel) Review SIMPLE SUMMARY: A subset of colorectal cancers (CRCs) displays deficient DNA mismatch repair (dMMR) that leads to microsatellite instability (MSI). These tumors have distinct clinicopathological features and have been associated with a more favorable prognosis. Knowledge of mismatch repair (MMR) status has important implications for disease diagnosis, surgical intervention, and adjuvant treatment decisions. ABSTRACT: Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Universal MMR/MSI testing is standard of care for all patients with newly diagnosed CRC based on multi-society guidelines in the United States. Such testing is intended to identify patients with Lynch Syndrome due to a germline mutation in an MMR gene, but also detects those with sporadic dMMR/MSI-high CRCs. The prognostic utility of MMR/MSI status in non-metastatic colorectal cancer has been studied extensively, yet more limited data are available for its predictive utility. Results have not been entirely consistent due to potential stage-related differences and limited numbers of dMMR/MSI-H patients included in the studies. In this review, we summarize the current evidence for the prognostic and predictive value of dMMR/MSI-H in non-metastatic CRC, and discuss the use of this biomarker for patient management and treatment decisions in clinical practice. MDPI 2021-01-15 /pmc/articles/PMC7830023/ /pubmed/33467526 http://dx.doi.org/10.3390/cancers13020300 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jin, Zhaohui Sinicrope, Frank A. Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer |
title | Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer |
title_full | Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer |
title_fullStr | Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer |
title_full_unstemmed | Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer |
title_short | Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer |
title_sort | prognostic and predictive values of mismatch repair deficiency in non-metastatic colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830023/ https://www.ncbi.nlm.nih.gov/pubmed/33467526 http://dx.doi.org/10.3390/cancers13020300 |
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