Cargando…

Molecular Delivery of Cytotoxic Agents via Integrin Activation

SIMPLE SUMMARY: Chemotherapy constituted a cornerstone in cancer treatment, but it suffers from non-selective drug cytotoxicity; an active drug targeting exerted by covalent conjugates between antitumor agents and some integrin ligands should have a more selective antitumor efficacy and could be an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cirillo, Martina, Giacomini, Daria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830197/ https://www.ncbi.nlm.nih.gov/pubmed/33467465 http://dx.doi.org/10.3390/cancers13020299

Ejemplares similares

Selective Integrin Ligands Promote Cell Internalization of the Antineoplastic Agent Fluorouracil
por: Baiula, Monica, et al.
Publicado: (2021)

Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators
por: Tolomelli, Alessandra, et al.
Publicado: (2017)

Leukocyte Integrin Antagonists as a Novel Option to Treat Dry Age-Related Macular Degeneration
por: Baiula, Monica, et al.
Publicado: (2021)

Integrin-Targeting Peptides for the Design of Functional Cell-Responsive Biomaterials
por: Zhao, Junwei, et al.
Publicado: (2020)

Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
por: Asrorov, Akmal M., et al.
Publicado: (2022)

Integrin Targeted Delivery of Radiotherapeutics
por: Liu, Zhaofei, et al.
Publicado: (2011)

Integrin Targeted Delivery of Chemotherapeutics
por: Chen, Kai, et al.
Publicado: (2011)

Integrin Targeted Delivery of Gene Therapeutics
por: Juliano, Rudy L, et al.
Publicado: (2011)

The Promise of Integrins as Effective Targets for Anticancer Agents
por: Rust, William L., et al.
Publicado: (2002)

Integrin Inhibitors as a Therapeutic Agent for Ovarian Cancer
por: Sawada, Kenjiro, et al.
Publicado: (2012)

Synthesis, molecular docking, and cytotoxicity of quinazolinone and dihydroquinazolinone derivatives as cytotoxic agents
por: Taayoshi, Fahimeh, et al.
Publicado: (2022)

Combining Biologically Active β-Lactams Integrin Agonists with Poly(l-lactic acid) Nanofibers: Enhancement of Human Mesenchymal Stem Cell Adhesion
por: Martelli, Giulia, et al.
Publicado: (2020)

Integrin activation
por: Ginsberg, Mark H.
Publicado: (2014)

Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as a New Integrin Ligand
por: Takada, Yoshikazu, et al.
Publicado: (2023)

Application of Molecular Ultrasound for Imaging Integrin Expression
por: Kiessling, Fabian, et al.
Publicado: (2011)

Delivery of Theranostic Nanoparticles to Various Cancers by Means of Integrin-Binding Peptides
por: Egorova, Elena A., et al.
Publicado: (2022)

The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy
por: Lu, Xinjie, et al.
Publicado: (2008)

Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity
por: Wang, Mitchell S., et al.
Publicado: (2022)

Integrin activation takes shape
por: Liddington, R.C., et al.
Publicado: (2002)

Role of Integrins in Sperm Activation and Fertilization
por: Merc, Veronika, et al.
Publicado: (2021)

Integrin Activation: Implications for Axon Regeneration
por: Cheah, Menghon, et al.
Publicado: (2018)

Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
por: Skwarczynski, Mariusz, et al.
Publicado: (2022)

Molecular Modeling Insights into the Structure and Behavior of Integrins: A Review
por: Tvaroška, Igor, et al.
Publicado: (2023)

Turning Microbial AhR Agonists into Therapeutic Agents via Drug Delivery Systems
por: Puccetti, Matteo, et al.
Publicado: (2023)

Using force to visualize conformational activation of integrins
por: Boettiger, David
Publicado: (2012)

The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents
por: Catalani, Elisabetta, et al.
Publicado: (2019)

Regulation of Dynamic Cell Adhesion by Integrin-Integrin Crosstalk
por: Gahmberg, Carl G., et al.
Publicado: (2022)

Host-Derived Cytotoxic Agents in Chronic Inflammation and Disease Progression
por: Arnhold, Jürgen
Publicado: (2023)

Nanocomposites as biomolecules delivery agents in nanomedicine
por: Bamburowicz-Klimkowska, Magdalena, et al.
Publicado: (2019)

Integrins in disguise - mechanosensors in Saccharomyces cerevisiae as functional integrin analogues
por: Elhasi, Tarek, et al.
Publicado: (2019)

The role of integrins in TGFβ activation in the tumour stroma
por: Khan, Zareen, et al.
Publicado: (2016)

ConFERMing the role of talin in integrin activation and mechanosignaling
por: Bachmann, Michael, et al.
Publicado: (2023)

Delayed adverse events in phase I trials of molecularly targeted and cytotoxic agents
por: Jordan, Emma J., et al.
Publicado: (2018)

The integrins
por: Takada, Yoshikazu, et al.
Publicado: (2007)

Side chain effect in the modulation of α(v)β(3)/α(5)β(1) integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems
por: Ferrazzano, Lucia, et al.
Publicado: (2020)

Molecular and Cellular Mechanisms of Cytotoxic Activity of Vanadium Compounds against Cancer Cells
por: Kowalski, Szymon, et al.
Publicado: (2020)

β4-integrin-mediated cytotoxic activity of AexU in human prostate cancer PC3 cells
por: KUMANO, MASAFUMI, et al.
Publicado: (2013)

Synthesis and In Vitro Cytotoxic Activity of Novel Chalcone-Like Agents
por: Letafat, Bahram, et al.
Publicado: (2013)

Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents
por: Olson, Oakley C., et al.
Publicado: (2017)

Cytotoxic Activity of Antineoplastic Agents on Fertility: A Systematic Review
por: Moura, Gabriel Acácio de, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1rfrb3god7jei7eamen15t33ms