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Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast

Fasting is becoming an increasingly popular practice. Nevertheless, its clinical benefits and possible inconveniences remain limitedly evaluated. We observed the effects of a seven-day fast conducted in a non-medical center located in the Swiss Alps. Clinical parameters were measured on the first an...

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Autores principales: Galetti, Valeria, Brnic, Marica, Lotin, Benjamin, Frigeri, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830333/
https://www.ncbi.nlm.nih.gov/pubmed/33477356
http://dx.doi.org/10.3390/nu13010255
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author Galetti, Valeria
Brnic, Marica
Lotin, Benjamin
Frigeri, Mauro
author_facet Galetti, Valeria
Brnic, Marica
Lotin, Benjamin
Frigeri, Mauro
author_sort Galetti, Valeria
collection PubMed
description Fasting is becoming an increasingly popular practice. Nevertheless, its clinical benefits and possible inconveniences remain limitedly evaluated. We observed the effects of a seven-day fast conducted in a non-medical center located in the Swiss Alps. Clinical parameters were measured on the first and last day of fasting (D1 and D7), and two months later (D60). Among the 40 participants, blood analyses were done on 25 persons with an increased metabolic risk, with the primary goal of assessing the lasting effect on low-density lipoprotein (LDL) cholesterol. By comparing D60 with D1, high-density lipoprotein cholesterol (HDL) (+0.15 mmol/L) and insulin-like growth factor-1 (IGF-1) (+2.05 mmol/L) increased (both p < 0.009), all other blood parameters (LDL, glucose, total cholesterol, triglycerides, C-reactive protein (CRP)) did not change; weight (−0.97 kg) and hearth rate (−7.31 min(−1)) decreased (both p < 0.006). By comparing D7 with D1, total cholesterol (+0.44 mmol/L), triglycerides (+0.37 mmol/L) and CRP (+3.37 mg/L) increased (all p < 0.02). The lack of LDL variation at D60 may be due to the low metabolic risk level of the participants. The increase of total cholesterol, triglycerides and CRP at D7 warrants studies to understand whether such fluctuations represent a stress reaction to the fasting state, which may vary in different fasting types.
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spelling pubmed-78303332021-01-26 Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast Galetti, Valeria Brnic, Marica Lotin, Benjamin Frigeri, Mauro Nutrients Article Fasting is becoming an increasingly popular practice. Nevertheless, its clinical benefits and possible inconveniences remain limitedly evaluated. We observed the effects of a seven-day fast conducted in a non-medical center located in the Swiss Alps. Clinical parameters were measured on the first and last day of fasting (D1 and D7), and two months later (D60). Among the 40 participants, blood analyses were done on 25 persons with an increased metabolic risk, with the primary goal of assessing the lasting effect on low-density lipoprotein (LDL) cholesterol. By comparing D60 with D1, high-density lipoprotein cholesterol (HDL) (+0.15 mmol/L) and insulin-like growth factor-1 (IGF-1) (+2.05 mmol/L) increased (both p < 0.009), all other blood parameters (LDL, glucose, total cholesterol, triglycerides, C-reactive protein (CRP)) did not change; weight (−0.97 kg) and hearth rate (−7.31 min(−1)) decreased (both p < 0.006). By comparing D7 with D1, total cholesterol (+0.44 mmol/L), triglycerides (+0.37 mmol/L) and CRP (+3.37 mg/L) increased (all p < 0.02). The lack of LDL variation at D60 may be due to the low metabolic risk level of the participants. The increase of total cholesterol, triglycerides and CRP at D7 warrants studies to understand whether such fluctuations represent a stress reaction to the fasting state, which may vary in different fasting types. MDPI 2021-01-17 /pmc/articles/PMC7830333/ /pubmed/33477356 http://dx.doi.org/10.3390/nu13010255 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Galetti, Valeria
Brnic, Marica
Lotin, Benjamin
Frigeri, Mauro
Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast
title Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast
title_full Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast
title_fullStr Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast
title_full_unstemmed Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast
title_short Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast
title_sort observational study of lipid profile and c-reactive protein after a seven-day fast
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830333/
https://www.ncbi.nlm.nih.gov/pubmed/33477356
http://dx.doi.org/10.3390/nu13010255
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