Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review

This narrative review explores the pathophysiology, geographic variation, and historical developments underlying the selection of fixed ratio versus whole blood resuscitation for hemorrhaging trauma patients. We also detail a physiologically driven and goal-directed alternative to fixed ratio and wh...

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Autores principales: Walsh, Mark, Moore, Ernest E., Moore, Hunter B., Thomas, Scott, Kwaan, Hau C., Speybroeck, Jacob, Marsee, Mathew, Bunch, Connor M., Stillson, John, Thomas, Anthony V., Grisoli, Annie, Aversa, John, Fulkerson, Daniel, Vande Lune, Stefani, Sjeklocha, Lucas, Tran, Quincy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830337/
https://www.ncbi.nlm.nih.gov/pubmed/33477257
http://dx.doi.org/10.3390/jcm10020320
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author Walsh, Mark
Moore, Ernest E.
Moore, Hunter B.
Thomas, Scott
Kwaan, Hau C.
Speybroeck, Jacob
Marsee, Mathew
Bunch, Connor M.
Stillson, John
Thomas, Anthony V.
Grisoli, Annie
Aversa, John
Fulkerson, Daniel
Vande Lune, Stefani
Sjeklocha, Lucas
Tran, Quincy K.
author_facet Walsh, Mark
Moore, Ernest E.
Moore, Hunter B.
Thomas, Scott
Kwaan, Hau C.
Speybroeck, Jacob
Marsee, Mathew
Bunch, Connor M.
Stillson, John
Thomas, Anthony V.
Grisoli, Annie
Aversa, John
Fulkerson, Daniel
Vande Lune, Stefani
Sjeklocha, Lucas
Tran, Quincy K.
author_sort Walsh, Mark
collection PubMed
description This narrative review explores the pathophysiology, geographic variation, and historical developments underlying the selection of fixed ratio versus whole blood resuscitation for hemorrhaging trauma patients. We also detail a physiologically driven and goal-directed alternative to fixed ratio and whole blood, whereby viscoelastic testing guides the administration of blood components and factor concentrates to the severely bleeding trauma patient. The major studies of each resuscitation method are highlighted, and upcoming comparative trials are detailed.
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spelling pubmed-78303372021-01-26 Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review Walsh, Mark Moore, Ernest E. Moore, Hunter B. Thomas, Scott Kwaan, Hau C. Speybroeck, Jacob Marsee, Mathew Bunch, Connor M. Stillson, John Thomas, Anthony V. Grisoli, Annie Aversa, John Fulkerson, Daniel Vande Lune, Stefani Sjeklocha, Lucas Tran, Quincy K. J Clin Med Review This narrative review explores the pathophysiology, geographic variation, and historical developments underlying the selection of fixed ratio versus whole blood resuscitation for hemorrhaging trauma patients. We also detail a physiologically driven and goal-directed alternative to fixed ratio and whole blood, whereby viscoelastic testing guides the administration of blood components and factor concentrates to the severely bleeding trauma patient. The major studies of each resuscitation method are highlighted, and upcoming comparative trials are detailed. MDPI 2021-01-17 /pmc/articles/PMC7830337/ /pubmed/33477257 http://dx.doi.org/10.3390/jcm10020320 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Walsh, Mark
Moore, Ernest E.
Moore, Hunter B.
Thomas, Scott
Kwaan, Hau C.
Speybroeck, Jacob
Marsee, Mathew
Bunch, Connor M.
Stillson, John
Thomas, Anthony V.
Grisoli, Annie
Aversa, John
Fulkerson, Daniel
Vande Lune, Stefani
Sjeklocha, Lucas
Tran, Quincy K.
Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review
title Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review
title_full Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review
title_fullStr Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review
title_full_unstemmed Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review
title_short Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review
title_sort whole blood, fixed ratio, or goal-directed blood component therapy for the initial resuscitation of severely hemorrhaging trauma patients: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830337/
https://www.ncbi.nlm.nih.gov/pubmed/33477257
http://dx.doi.org/10.3390/jcm10020320
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