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Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing

Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus). CA is typically co-formulated with broad-spectrum β‑lactam antibiotics such as amoxicillin, conferring them high potential to treat disease...

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Detalles Bibliográficos
Autores principales:	López-Agudelo, Víctor A., Gómez-Ríos, David, Ramirez-Malule, Howard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830376/ https://www.ncbi.nlm.nih.gov/pubmed/33477401 http://dx.doi.org/10.3390/antibiotics10010084

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