NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure–Activity Relationships

The saliva of blood-sucking leeches contains a plethora of anticoagulant substances. One of these compounds derived from Haementeria ghilianii, the 66mer three-disulfide-bonded peptide tridegin, specifically inhibits the blood coagulation factor FXIIIa. Tridegin represents a potential tool for antit...

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Detalles Bibliográficos
Autores principales: Schmitz, Thomas, Paul George, Ajay Abisheck, Nubbemeyer, Britta, Bäuml, Charlotte A., Steinmetzer, Torsten, Ohlenschläger, Oliver, Biswas, Arijit, Imhof, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830451/
https://www.ncbi.nlm.nih.gov/pubmed/33477282
http://dx.doi.org/10.3390/ijms22020880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830451/
https://www.ncbi.nlm.nih.gov/pubmed/33477282
http://dx.doi.org/10.3390/ijms22020880

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