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Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome

Over the past two decades, research into the role of the gut microbiome in regulating the central nervous system has rapidly increased. Several neurodevelopmental diseases have been linked to the unbalance of gut microbiota, including autism. Children on the autism spectrum often suffer from gastroi...

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Autores principales: Fu, Shih-Chen, Lee, Chung-Han, Wang, Hsiuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830459/
https://www.ncbi.nlm.nih.gov/pubmed/33466802
http://dx.doi.org/10.3390/ijerph18020667
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author Fu, Shih-Chen
Lee, Chung-Han
Wang, Hsiuying
author_facet Fu, Shih-Chen
Lee, Chung-Han
Wang, Hsiuying
author_sort Fu, Shih-Chen
collection PubMed
description Over the past two decades, research into the role of the gut microbiome in regulating the central nervous system has rapidly increased. Several neurodevelopmental diseases have been linked to the unbalance of gut microbiota, including autism. Children on the autism spectrum often suffer from gastrointestinal symptoms, including constipation, which is four times more prevalent than it is in children without autism spectrum disorders (ASD). Although studies in animals have shown the crucial role of the microbiota in key aspects of neurodevelopment, there is currently no consensus on how the alteration of microbial composition affects the pathogenesis of ASD, let alone how it exerts an impact on the following comorbidities. In our study, we were able to control the effects of constipation on gut dysbiosis and distinguish neuropathological-related and gastrointestinal-related bacteria in ASD patients separately. By analyzing published data, eight additional bacteria significantly altered in autistic individuals were identified in our study. All of them had a decreased relative abundance in ASD patients, except Lactobacillaceae and Peptostreptococcaceae. Eighteen and eleven bacteria were significantly correlated with ASD symptoms and constipation, respectively. Among those, six bacteria were overlapped between the groups. We have found another six bacteria highly associated with constipation status in ASD patients only. By conducting Welch’s t-test, we were able to demonstrate the critical roles of microbes in ASD core and gastrointestinal symptoms and raised the hypotheses of their confounding and mediating effects on the relationship between the two symptoms.
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spelling pubmed-78304592021-01-26 Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome Fu, Shih-Chen Lee, Chung-Han Wang, Hsiuying Int J Environ Res Public Health Article Over the past two decades, research into the role of the gut microbiome in regulating the central nervous system has rapidly increased. Several neurodevelopmental diseases have been linked to the unbalance of gut microbiota, including autism. Children on the autism spectrum often suffer from gastrointestinal symptoms, including constipation, which is four times more prevalent than it is in children without autism spectrum disorders (ASD). Although studies in animals have shown the crucial role of the microbiota in key aspects of neurodevelopment, there is currently no consensus on how the alteration of microbial composition affects the pathogenesis of ASD, let alone how it exerts an impact on the following comorbidities. In our study, we were able to control the effects of constipation on gut dysbiosis and distinguish neuropathological-related and gastrointestinal-related bacteria in ASD patients separately. By analyzing published data, eight additional bacteria significantly altered in autistic individuals were identified in our study. All of them had a decreased relative abundance in ASD patients, except Lactobacillaceae and Peptostreptococcaceae. Eighteen and eleven bacteria were significantly correlated with ASD symptoms and constipation, respectively. Among those, six bacteria were overlapped between the groups. We have found another six bacteria highly associated with constipation status in ASD patients only. By conducting Welch’s t-test, we were able to demonstrate the critical roles of microbes in ASD core and gastrointestinal symptoms and raised the hypotheses of their confounding and mediating effects on the relationship between the two symptoms. MDPI 2021-01-14 2021-01 /pmc/articles/PMC7830459/ /pubmed/33466802 http://dx.doi.org/10.3390/ijerph18020667 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Shih-Chen
Lee, Chung-Han
Wang, Hsiuying
Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome
title Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome
title_full Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome
title_fullStr Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome
title_full_unstemmed Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome
title_short Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome
title_sort exploring the association of autism spectrum disorders and constipation through analysis of the gut microbiome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830459/
https://www.ncbi.nlm.nih.gov/pubmed/33466802
http://dx.doi.org/10.3390/ijerph18020667
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