Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery

The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irradiation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied e...

Descripción completa

Detalles Bibliográficos
Autores principales: Kudelin, Anton I., Papathanasiou, Konstantinos, Isaeva, Vera, Caro, Juergen, Salmi, Tapio, Kustov, Leonid M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830474/
https://www.ncbi.nlm.nih.gov/pubmed/33467467
http://dx.doi.org/10.3390/molecules26020426
_version_ 1783641422799306752
author Kudelin, Anton I.
Papathanasiou, Konstantinos
Isaeva, Vera
Caro, Juergen
Salmi, Tapio
Kustov, Leonid M.
author_facet Kudelin, Anton I.
Papathanasiou, Konstantinos
Isaeva, Vera
Caro, Juergen
Salmi, Tapio
Kustov, Leonid M.
author_sort Kudelin, Anton I.
collection PubMed
description The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irradiation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied employing the Gaussian and Plane Wave approach of the Density Functional Theory. The structure of CPO-27-Mg persists after the adsorption of aspirin or paracetamol and their desorption energies, being quite high, decrease under solvent conditions.
format Online
Article
Text
id pubmed-7830474
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78304742021-01-26 Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery Kudelin, Anton I. Papathanasiou, Konstantinos Isaeva, Vera Caro, Juergen Salmi, Tapio Kustov, Leonid M. Molecules Article The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irradiation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied employing the Gaussian and Plane Wave approach of the Density Functional Theory. The structure of CPO-27-Mg persists after the adsorption of aspirin or paracetamol and their desorption energies, being quite high, decrease under solvent conditions. MDPI 2021-01-15 /pmc/articles/PMC7830474/ /pubmed/33467467 http://dx.doi.org/10.3390/molecules26020426 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kudelin, Anton I.
Papathanasiou, Konstantinos
Isaeva, Vera
Caro, Juergen
Salmi, Tapio
Kustov, Leonid M.
Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery
title Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery
title_full Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery
title_fullStr Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery
title_full_unstemmed Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery
title_short Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery
title_sort microwave-assisted synthesis, characterization and modeling of cpo-27-mg metal-organic framework for drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830474/
https://www.ncbi.nlm.nih.gov/pubmed/33467467
http://dx.doi.org/10.3390/molecules26020426
work_keys_str_mv AT kudelinantoni microwaveassistedsynthesischaracterizationandmodelingofcpo27mgmetalorganicframeworkfordrugdelivery
AT papathanasioukonstantinos microwaveassistedsynthesischaracterizationandmodelingofcpo27mgmetalorganicframeworkfordrugdelivery
AT isaevavera microwaveassistedsynthesischaracterizationandmodelingofcpo27mgmetalorganicframeworkfordrugdelivery
AT carojuergen microwaveassistedsynthesischaracterizationandmodelingofcpo27mgmetalorganicframeworkfordrugdelivery
AT salmitapio microwaveassistedsynthesischaracterizationandmodelingofcpo27mgmetalorganicframeworkfordrugdelivery
AT kustovleonidm microwaveassistedsynthesischaracterizationandmodelingofcpo27mgmetalorganicframeworkfordrugdelivery

Ejemplares similares