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PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate the expression of genes related to lipid and glucose metabolism and inflammation. There are three members: PPARα, PPARβ or PPARγ. PPARγ have several ligands. The natural agonists are ome...

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Autores principales: de Carvalho, Márcia V., Gonçalves-de-Albuquerque, Cassiano F., Silva, Adriana R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830538/
https://www.ncbi.nlm.nih.gov/pubmed/33467433
http://dx.doi.org/10.3390/ijms22020805
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author de Carvalho, Márcia V.
Gonçalves-de-Albuquerque, Cassiano F.
Silva, Adriana R.
author_facet de Carvalho, Márcia V.
Gonçalves-de-Albuquerque, Cassiano F.
Silva, Adriana R.
author_sort de Carvalho, Márcia V.
collection PubMed
description Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate the expression of genes related to lipid and glucose metabolism and inflammation. There are three members: PPARα, PPARβ or PPARγ. PPARγ have several ligands. The natural agonists are omega 9, curcumin, eicosanoids and others. Among the synthetic ligands, we highlight the thiazolidinediones, clinically used as an antidiabetic. Many of these studies involve natural or synthetic products in different pathologies. The mechanisms that regulate PPARγ involve post-translational modifications, such as phosphorylation, sumoylation and ubiquitination, among others. It is known that anti-inflammatory mechanisms involve the inhibition of other transcription factors, such as nuclear factor kB(NFκB), signal transducer and activator of transcription (STAT) or activator protein 1 (AP-1), or intracellular signaling proteins such as mitogen-activated protein (MAP) kinases. PPARγ transrepresses other transcription factors and consequently inhibits gene expression of inflammatory mediators, known as biomarkers for morbidity and mortality, leading to control of the exacerbated inflammation that occurs, for instance, in lung injury/acute respiratory distress. Many studies have shown the therapeutic potentials of PPARγ on pulmonary diseases. Herein, we describe activities of the PPARγ as a modulator of inflammation, focusing on lung injury and including definition and mechanisms of regulation, biological effects and molecular targets, and its role in lung diseases caused by inflammatory stimuli, bacteria and virus, and molecular-based therapy.
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spelling pubmed-78305382021-01-26 PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases de Carvalho, Márcia V. Gonçalves-de-Albuquerque, Cassiano F. Silva, Adriana R. Int J Mol Sci Review Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate the expression of genes related to lipid and glucose metabolism and inflammation. There are three members: PPARα, PPARβ or PPARγ. PPARγ have several ligands. The natural agonists are omega 9, curcumin, eicosanoids and others. Among the synthetic ligands, we highlight the thiazolidinediones, clinically used as an antidiabetic. Many of these studies involve natural or synthetic products in different pathologies. The mechanisms that regulate PPARγ involve post-translational modifications, such as phosphorylation, sumoylation and ubiquitination, among others. It is known that anti-inflammatory mechanisms involve the inhibition of other transcription factors, such as nuclear factor kB(NFκB), signal transducer and activator of transcription (STAT) or activator protein 1 (AP-1), or intracellular signaling proteins such as mitogen-activated protein (MAP) kinases. PPARγ transrepresses other transcription factors and consequently inhibits gene expression of inflammatory mediators, known as biomarkers for morbidity and mortality, leading to control of the exacerbated inflammation that occurs, for instance, in lung injury/acute respiratory distress. Many studies have shown the therapeutic potentials of PPARγ on pulmonary diseases. Herein, we describe activities of the PPARγ as a modulator of inflammation, focusing on lung injury and including definition and mechanisms of regulation, biological effects and molecular targets, and its role in lung diseases caused by inflammatory stimuli, bacteria and virus, and molecular-based therapy. MDPI 2021-01-15 /pmc/articles/PMC7830538/ /pubmed/33467433 http://dx.doi.org/10.3390/ijms22020805 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Carvalho, Márcia V.
Gonçalves-de-Albuquerque, Cassiano F.
Silva, Adriana R.
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_full PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_fullStr PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_full_unstemmed PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_short PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_sort ppar gamma: from definition to molecular targets and therapy of lung diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830538/
https://www.ncbi.nlm.nih.gov/pubmed/33467433
http://dx.doi.org/10.3390/ijms22020805
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