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The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study

Whereas excessive alcohol consumption increases liver disease incidence and mortality, evidence on the risk associated with specific drinking patterns is emerging. We assessed the impact of binge drinking on mortality and liver disease in the Swiss HIV Cohort Study. All participants with follow-up b...

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Autores principales: Surial, Bernard, Bertholet, Nicolas, Daeppen, Jean-Bernard, Darling, Katharine E. A., Calmy, Alexandra, Günthard, Huldrych F., Stöckle, Marcel, Bernasconi, Enos, Schmid, Patrick, Rauch, Andri, Furrer, Hansjakob, Wandeler, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830571/
https://www.ncbi.nlm.nih.gov/pubmed/33466907
http://dx.doi.org/10.3390/jcm10020295
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author Surial, Bernard
Bertholet, Nicolas
Daeppen, Jean-Bernard
Darling, Katharine E. A.
Calmy, Alexandra
Günthard, Huldrych F.
Stöckle, Marcel
Bernasconi, Enos
Schmid, Patrick
Rauch, Andri
Furrer, Hansjakob
Wandeler, Gilles
author_facet Surial, Bernard
Bertholet, Nicolas
Daeppen, Jean-Bernard
Darling, Katharine E. A.
Calmy, Alexandra
Günthard, Huldrych F.
Stöckle, Marcel
Bernasconi, Enos
Schmid, Patrick
Rauch, Andri
Furrer, Hansjakob
Wandeler, Gilles
author_sort Surial, Bernard
collection PubMed
description Whereas excessive alcohol consumption increases liver disease incidence and mortality, evidence on the risk associated with specific drinking patterns is emerging. We assessed the impact of binge drinking on mortality and liver disease in the Swiss HIV Cohort Study. All participants with follow-up between 2013 and 2020 were categorized into one of four drinking pattern groups: “abstinence”, “non-hazardous drinking”, “hazardous but not binge drinking” (Alcohol Use Disorder Identification Test Consumption [AUDIT-C] score ≥ 3 in women and ≥4 in men), and “binge drinking” (≥6 drinks/occasion more than monthly). We estimated adjusted incidence rate ratios (aIRR) for all-cause mortality, liver-related mortality and liver-related events using multivariable quasi-Poisson regression. Among 11,849 individuals (median follow-up 6.8 years), 470 died (incidence rate 7.1/1000 person-years, 95% confidence interval [CI] 6.5–7.8), 37 experienced a liver-related death (0.6/1000, 0.4–0.8), and 239 liver-related events occurred (3.7/1000, 3.2–4.2). Compared to individuals with non-hazardous drinking, those reporting binge drinking were more likely to die (all-cause mortality: aIRR 1.9, 95% CI 1.3–2.7; liver-related mortality: 3.6, 0.9–13.9) and to experience a liver-related event (3.8, 2.4–5.8). We observed no difference in outcomes between participants reporting non-hazardous and hazardous without binge drinking. These findings highlight the importance of assessing drinking patterns in clinical routine.
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spelling pubmed-78305712021-01-26 The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study Surial, Bernard Bertholet, Nicolas Daeppen, Jean-Bernard Darling, Katharine E. A. Calmy, Alexandra Günthard, Huldrych F. Stöckle, Marcel Bernasconi, Enos Schmid, Patrick Rauch, Andri Furrer, Hansjakob Wandeler, Gilles J Clin Med Article Whereas excessive alcohol consumption increases liver disease incidence and mortality, evidence on the risk associated with specific drinking patterns is emerging. We assessed the impact of binge drinking on mortality and liver disease in the Swiss HIV Cohort Study. All participants with follow-up between 2013 and 2020 were categorized into one of four drinking pattern groups: “abstinence”, “non-hazardous drinking”, “hazardous but not binge drinking” (Alcohol Use Disorder Identification Test Consumption [AUDIT-C] score ≥ 3 in women and ≥4 in men), and “binge drinking” (≥6 drinks/occasion more than monthly). We estimated adjusted incidence rate ratios (aIRR) for all-cause mortality, liver-related mortality and liver-related events using multivariable quasi-Poisson regression. Among 11,849 individuals (median follow-up 6.8 years), 470 died (incidence rate 7.1/1000 person-years, 95% confidence interval [CI] 6.5–7.8), 37 experienced a liver-related death (0.6/1000, 0.4–0.8), and 239 liver-related events occurred (3.7/1000, 3.2–4.2). Compared to individuals with non-hazardous drinking, those reporting binge drinking were more likely to die (all-cause mortality: aIRR 1.9, 95% CI 1.3–2.7; liver-related mortality: 3.6, 0.9–13.9) and to experience a liver-related event (3.8, 2.4–5.8). We observed no difference in outcomes between participants reporting non-hazardous and hazardous without binge drinking. These findings highlight the importance of assessing drinking patterns in clinical routine. MDPI 2021-01-14 /pmc/articles/PMC7830571/ /pubmed/33466907 http://dx.doi.org/10.3390/jcm10020295 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Surial, Bernard
Bertholet, Nicolas
Daeppen, Jean-Bernard
Darling, Katharine E. A.
Calmy, Alexandra
Günthard, Huldrych F.
Stöckle, Marcel
Bernasconi, Enos
Schmid, Patrick
Rauch, Andri
Furrer, Hansjakob
Wandeler, Gilles
The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study
title The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study
title_full The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study
title_fullStr The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study
title_full_unstemmed The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study
title_short The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study
title_sort impact of binge drinking on mortality and liver disease in the swiss hiv cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830571/
https://www.ncbi.nlm.nih.gov/pubmed/33466907
http://dx.doi.org/10.3390/jcm10020295
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