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Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial

SIMPLE SUMMARY: Endometritis is one of the most common disorders during the postpartum period in dairy cows. We investigated the efficacy of intrauterine infusion of a chitosan solution in uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive...

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Autores principales: Okawa, Hiroaki, Wijayagunawardane, Missaka M.P., Vos, Peter L.A.M., Yamato, Osamu, Taniguchi, Masayasu, Takagi, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830579/
https://www.ncbi.nlm.nih.gov/pubmed/33467578
http://dx.doi.org/10.3390/ani11010197
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author Okawa, Hiroaki
Wijayagunawardane, Missaka M.P.
Vos, Peter L.A.M.
Yamato, Osamu
Taniguchi, Masayasu
Takagi, Mitsuhiro
author_facet Okawa, Hiroaki
Wijayagunawardane, Missaka M.P.
Vos, Peter L.A.M.
Yamato, Osamu
Taniguchi, Masayasu
Takagi, Mitsuhiro
author_sort Okawa, Hiroaki
collection PubMed
description SIMPLE SUMMARY: Endometritis is one of the most common disorders during the postpartum period in dairy cows. We investigated the efficacy of intrauterine infusion of a chitosan solution in uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive performance. We found that, compared to the absence of treatment, chitosan solution treatment during the early postpartum period (approximately 3 weeks after parturition) accelerated uterine recovery after parturition of dairy cows. These findings suggest that the administration of chitosan solution once in the early postpartum period may have antimicrobial effects on the uterus. We suggest that chitosan solution is a potential therapeutic candidate for endometritis that may replace prostaglandin F(2α) or antibiotic treatments(.) ABSTRACT: This study investigated the efficacy of intrauterine infusion of a chitosan solution (CHT) on uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive performance. In Experiment 1, cows with endometritis at 3 weeks postpartum were administered CHT (n = 5) and prostaglandin F(2α) (PGF(2α)) (n = 4). Untreated cows (n = 7) served as the control group. In Experiment 2, 18 cows with a normally recovered uterus at the fresh cow check (mean, 35 days postpartum) were assigned to the CHT (n = 10) and control (n = 8) groups, and intrauterine infusion was conducted in the CHT group. Overall, in Experiment 1, the percentage of polymorphonuclear leukocytes significantly declined in the CHT group (32.3 ± 10.2 to 5.5 ± 2.4, p < 0.05) from week 3 to week 5, but no decline occurred in the PGF(2α) and control groups. In Experiment 2, the CHT and control groups showed no significant differences in reproductive parameters, suggesting the absence of adverse effects of CHT on fertility. These results suggest that intrauterine infusion of CHT in the early postpartum period effectively accelerates uterine recovery from endometritis and might be a suitable replacement for PGF(2α) administration.
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spelling pubmed-78305792021-01-26 Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial Okawa, Hiroaki Wijayagunawardane, Missaka M.P. Vos, Peter L.A.M. Yamato, Osamu Taniguchi, Masayasu Takagi, Mitsuhiro Animals (Basel) Article SIMPLE SUMMARY: Endometritis is one of the most common disorders during the postpartum period in dairy cows. We investigated the efficacy of intrauterine infusion of a chitosan solution in uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive performance. We found that, compared to the absence of treatment, chitosan solution treatment during the early postpartum period (approximately 3 weeks after parturition) accelerated uterine recovery after parturition of dairy cows. These findings suggest that the administration of chitosan solution once in the early postpartum period may have antimicrobial effects on the uterus. We suggest that chitosan solution is a potential therapeutic candidate for endometritis that may replace prostaglandin F(2α) or antibiotic treatments(.) ABSTRACT: This study investigated the efficacy of intrauterine infusion of a chitosan solution (CHT) on uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive performance. In Experiment 1, cows with endometritis at 3 weeks postpartum were administered CHT (n = 5) and prostaglandin F(2α) (PGF(2α)) (n = 4). Untreated cows (n = 7) served as the control group. In Experiment 2, 18 cows with a normally recovered uterus at the fresh cow check (mean, 35 days postpartum) were assigned to the CHT (n = 10) and control (n = 8) groups, and intrauterine infusion was conducted in the CHT group. Overall, in Experiment 1, the percentage of polymorphonuclear leukocytes significantly declined in the CHT group (32.3 ± 10.2 to 5.5 ± 2.4, p < 0.05) from week 3 to week 5, but no decline occurred in the PGF(2α) and control groups. In Experiment 2, the CHT and control groups showed no significant differences in reproductive parameters, suggesting the absence of adverse effects of CHT on fertility. These results suggest that intrauterine infusion of CHT in the early postpartum period effectively accelerates uterine recovery from endometritis and might be a suitable replacement for PGF(2α) administration. MDPI 2021-01-15 /pmc/articles/PMC7830579/ /pubmed/33467578 http://dx.doi.org/10.3390/ani11010197 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Okawa, Hiroaki
Wijayagunawardane, Missaka M.P.
Vos, Peter L.A.M.
Yamato, Osamu
Taniguchi, Masayasu
Takagi, Mitsuhiro
Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial
title Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial
title_full Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial
title_fullStr Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial
title_full_unstemmed Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial
title_short Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial
title_sort effects of intrauterine infusion of a chitosan solution on recovery and subsequent reproductive performance of early postpartum dairy cows with endometritis: a pilot field trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830579/
https://www.ncbi.nlm.nih.gov/pubmed/33467578
http://dx.doi.org/10.3390/ani11010197
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