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Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Rapid eye movement (REM) sleep behavior disorder (RBD) is a risk factor for developing Parkinson’s disease (PD) and may represent its prodromal state. We compared neuropsychological and neuropsychiatric phenotypes of idiopathic (i) RBD, PD and healthy comparators (HC) in order to identify iRBD speci...

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Autores principales: Assogna, Francesca, Liguori, Claudio, Cravello, Luca, Macchiusi, Lucia, Belli, Claudia, Placidi, Fabio, Pierantozzi, Mariangela, Stefani, Alessandro, Mercuri, Bruno, Izzi, Francesca, Caltagirone, Carlo, Mercuri, Nicola B., Pontieri, Francesco E., Spalletta, Gianfranco, Pellicano, Clelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830588/
https://www.ncbi.nlm.nih.gov/pubmed/33467021
http://dx.doi.org/10.3390/jpm11010051
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author Assogna, Francesca
Liguori, Claudio
Cravello, Luca
Macchiusi, Lucia
Belli, Claudia
Placidi, Fabio
Pierantozzi, Mariangela
Stefani, Alessandro
Mercuri, Bruno
Izzi, Francesca
Caltagirone, Carlo
Mercuri, Nicola B.
Pontieri, Francesco E.
Spalletta, Gianfranco
Pellicano, Clelia
author_facet Assogna, Francesca
Liguori, Claudio
Cravello, Luca
Macchiusi, Lucia
Belli, Claudia
Placidi, Fabio
Pierantozzi, Mariangela
Stefani, Alessandro
Mercuri, Bruno
Izzi, Francesca
Caltagirone, Carlo
Mercuri, Nicola B.
Pontieri, Francesco E.
Spalletta, Gianfranco
Pellicano, Clelia
author_sort Assogna, Francesca
collection PubMed
description Rapid eye movement (REM) sleep behavior disorder (RBD) is a risk factor for developing Parkinson’s disease (PD) and may represent its prodromal state. We compared neuropsychological and neuropsychiatric phenotypes of idiopathic (i) RBD, PD and healthy comparators (HC) in order to identify iRBD specific characteristics. Thirty-eight patients with iRBD, 38 PD patients with RBD (PD + RBD), 38 PD patients without RBD (PD-RBD) and 38 HC underwent a comprehensive neurological, neuropsychological and neuropsychiatric evaluation. iRBD, PD + RBD and PD-RBD performed worse than HC in short-term verbal memory, praxia, language and executive functions. iRBD had higher levels of anxiety, depression, apathy and alexithymia than HC. iRBD had higher levels of apathy than PD + RBD. Both PD groups had higher levels of anxiety and depression than HC. Surprisingly, iRBD performed better than all groups in long-term verbal memory. Patients diagnosed with iRBD are characterized by poor global cognitive performance, but better long-term memory and higher levels of depression, anxiety, alexithymia and apathy. Alexithymia and apathy in patients diagnosed with iRBD may be the expression of precocious derangement of emotional regulation, subsequently observed also in PD. Cognitive and neuropsychiatric symptoms of iRBD are early clinical manifestations of widespread neurodegeneration.
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spelling pubmed-78305882021-01-26 Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease Assogna, Francesca Liguori, Claudio Cravello, Luca Macchiusi, Lucia Belli, Claudia Placidi, Fabio Pierantozzi, Mariangela Stefani, Alessandro Mercuri, Bruno Izzi, Francesca Caltagirone, Carlo Mercuri, Nicola B. Pontieri, Francesco E. Spalletta, Gianfranco Pellicano, Clelia J Pers Med Article Rapid eye movement (REM) sleep behavior disorder (RBD) is a risk factor for developing Parkinson’s disease (PD) and may represent its prodromal state. We compared neuropsychological and neuropsychiatric phenotypes of idiopathic (i) RBD, PD and healthy comparators (HC) in order to identify iRBD specific characteristics. Thirty-eight patients with iRBD, 38 PD patients with RBD (PD + RBD), 38 PD patients without RBD (PD-RBD) and 38 HC underwent a comprehensive neurological, neuropsychological and neuropsychiatric evaluation. iRBD, PD + RBD and PD-RBD performed worse than HC in short-term verbal memory, praxia, language and executive functions. iRBD had higher levels of anxiety, depression, apathy and alexithymia than HC. iRBD had higher levels of apathy than PD + RBD. Both PD groups had higher levels of anxiety and depression than HC. Surprisingly, iRBD performed better than all groups in long-term verbal memory. Patients diagnosed with iRBD are characterized by poor global cognitive performance, but better long-term memory and higher levels of depression, anxiety, alexithymia and apathy. Alexithymia and apathy in patients diagnosed with iRBD may be the expression of precocious derangement of emotional regulation, subsequently observed also in PD. Cognitive and neuropsychiatric symptoms of iRBD are early clinical manifestations of widespread neurodegeneration. MDPI 2021-01-16 /pmc/articles/PMC7830588/ /pubmed/33467021 http://dx.doi.org/10.3390/jpm11010051 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Assogna, Francesca
Liguori, Claudio
Cravello, Luca
Macchiusi, Lucia
Belli, Claudia
Placidi, Fabio
Pierantozzi, Mariangela
Stefani, Alessandro
Mercuri, Bruno
Izzi, Francesca
Caltagirone, Carlo
Mercuri, Nicola B.
Pontieri, Francesco E.
Spalletta, Gianfranco
Pellicano, Clelia
Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
title Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
title_full Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
title_fullStr Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
title_full_unstemmed Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
title_short Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
title_sort cognitive and neuropsychiatric profiles in idiopathic rapid eye movement sleep behavior disorder and parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830588/
https://www.ncbi.nlm.nih.gov/pubmed/33467021
http://dx.doi.org/10.3390/jpm11010051
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