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Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women

Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetri...

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Detalles Bibliográficos
Autores principales: Cruz-Lemini, Monica, Ferriols Perez, Elena, de la Cruz Conty, Maria Luisa, Caño Aguilar, Africa, Encinas Pardilla, Maria Begoña, Prats Rodríguez, Pilar, Muner Hernando, Marta, Forcen Acebal, Laura, Pintado Recarte, Pilar, Medina Mallen, Maria del Carmen, Perez Perez, Noelia, Canet Rodriguez, Judit, Villalba Yarza, Ana, Nieto Velasco, Olga, del Barrio Fernandez, Pablo Guillermo, Orizales Lago, Carmen Maria, Marcos Puig, Beatriz, Muñoz Abellana, Begoña, Fuentes Ricoy, Laura, Rodriguez Vicente, Agueda, Janeiro Freire, Maria Jesus, Alferez Alvarez-Mallo, Macarena, Casanova Pedraz, Cristina, Alomar Mateu, Onofre, Lesmes Heredia, Cristina, Wizner de Alva, Juan Carlos, Posadas San Juan, Alma, Macia Badia, Montserrat, Alvarez Colomo, Cristina, Sanchez Muñoz, Antonio, Pratcorona Alicart, Laia, Alonso Saiz, Ruben, Lopez Rodriguez, Monica, Barbancho Lopez, Maria Carmen, Meca Casbas, Marta Ruth, Vaquerizo Ruiz, Oscar, Moran Antolin, Eva, Nuñez Valera, Maria Jose, Fernandez Fernandez, Camino, Tubau Navarra, Albert, Cano Garcia, Alejandra Maria, Soldevilla Perez, Susana, Gattaca Abasolo, Irene, Adanez Garcia, Jose, Puertas Prieto, Alberto, Ostos Serna, Rosa, Guadix Martin, Maria del Pilar, Catalina Coello, Monica, Espuelas Malon, Silvia, Sainz Bueno, Jose Antonio, Granell Escobar, Maria Reyes, Cruz Melguizo, Sara, Martinez Perez, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830626/
https://www.ncbi.nlm.nih.gov/pubmed/33467629
http://dx.doi.org/10.3390/v13010112
Descripción
Sumario:Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13–3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.