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Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling

Cell can integrate the caspase family and mammalian target of rapamycin (mTOR) signaling in response to cellular stress triggered by environment. It is necessary here to elucidate the direct response and interaction mechanism between the two signaling pathways in regulating cell survival and determi...

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Autores principales: Yan, Junfang, Xie, Yi, Si, Jing, Gan, Lu, Li, Hongyan, Sun, Chao, Di, Cuixia, Zhang, Jinhua, Huang, Guomin, Zhang, Xuetian, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830632/
https://www.ncbi.nlm.nih.gov/pubmed/33467535
http://dx.doi.org/10.3390/ijms22020817
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author Yan, Junfang
Xie, Yi
Si, Jing
Gan, Lu
Li, Hongyan
Sun, Chao
Di, Cuixia
Zhang, Jinhua
Huang, Guomin
Zhang, Xuetian
Zhang, Hong
author_facet Yan, Junfang
Xie, Yi
Si, Jing
Gan, Lu
Li, Hongyan
Sun, Chao
Di, Cuixia
Zhang, Jinhua
Huang, Guomin
Zhang, Xuetian
Zhang, Hong
author_sort Yan, Junfang
collection PubMed
description Cell can integrate the caspase family and mammalian target of rapamycin (mTOR) signaling in response to cellular stress triggered by environment. It is necessary here to elucidate the direct response and interaction mechanism between the two signaling pathways in regulating cell survival and determining cell fate under cellular stress. Members of the caspase family are crucial regulators of inflammation, endoplasmic reticulum stress response and apoptosis. mTOR signaling is known to mediate cell growth, nutrition and metabolism. For instance, over-nutrition can cause the hyperactivation of mTOR signaling, which is associated with diabetes. Nutrition deprivation can inhibit mTOR signaling via SH3 domain-binding protein 4. It is striking that Ras GTPase-activating protein 1 is found to mediate cell survival in a caspase-dependent manner against increasing cellular stress, which describes a new model of apoptosis. The components of mTOR signaling-raptor can be cleaved by caspases to control cell growth. In addition, mTOR is identified to coordinate the defense process of the immune system by suppressing the vitality of caspase-1 or regulating other interferon regulatory factors. The present review discusses the roles of the caspase family or mTOR pathway against cellular stress and generalizes their interplay mechanism in cell fate determination.
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spelling pubmed-78306322021-01-26 Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling Yan, Junfang Xie, Yi Si, Jing Gan, Lu Li, Hongyan Sun, Chao Di, Cuixia Zhang, Jinhua Huang, Guomin Zhang, Xuetian Zhang, Hong Int J Mol Sci Review Cell can integrate the caspase family and mammalian target of rapamycin (mTOR) signaling in response to cellular stress triggered by environment. It is necessary here to elucidate the direct response and interaction mechanism between the two signaling pathways in regulating cell survival and determining cell fate under cellular stress. Members of the caspase family are crucial regulators of inflammation, endoplasmic reticulum stress response and apoptosis. mTOR signaling is known to mediate cell growth, nutrition and metabolism. For instance, over-nutrition can cause the hyperactivation of mTOR signaling, which is associated with diabetes. Nutrition deprivation can inhibit mTOR signaling via SH3 domain-binding protein 4. It is striking that Ras GTPase-activating protein 1 is found to mediate cell survival in a caspase-dependent manner against increasing cellular stress, which describes a new model of apoptosis. The components of mTOR signaling-raptor can be cleaved by caspases to control cell growth. In addition, mTOR is identified to coordinate the defense process of the immune system by suppressing the vitality of caspase-1 or regulating other interferon regulatory factors. The present review discusses the roles of the caspase family or mTOR pathway against cellular stress and generalizes their interplay mechanism in cell fate determination. MDPI 2021-01-15 /pmc/articles/PMC7830632/ /pubmed/33467535 http://dx.doi.org/10.3390/ijms22020817 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yan, Junfang
Xie, Yi
Si, Jing
Gan, Lu
Li, Hongyan
Sun, Chao
Di, Cuixia
Zhang, Jinhua
Huang, Guomin
Zhang, Xuetian
Zhang, Hong
Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
title Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
title_full Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
title_fullStr Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
title_full_unstemmed Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
title_short Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
title_sort crosstalk of the caspase family and mammalian target of rapamycin signaling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830632/
https://www.ncbi.nlm.nih.gov/pubmed/33467535
http://dx.doi.org/10.3390/ijms22020817
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