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MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants

Perioperative hypersensitivity (POH) to the neuromuscular blocking drug (NMBD) rocuronium was previously thought to be IgE and mast cell (MC)-mediated. However, the recent seminal observation that rocuronium induces degranulation in murine peritoneal MCs (PMCs) via Mas-related G protein-coupled rece...

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Detalles Bibliográficos
Autores principales:	Chompunud Na Ayudhya, Chalatip, Amponnawarat, Aetas, Roy, Saptarshi, Oskeritzian, Carole A., Ali, Hydar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830812/ https://www.ncbi.nlm.nih.gov/pubmed/33467419 http://dx.doi.org/10.3390/cells10010156

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