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Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds
The antitussive, antioxidant, and anti-inflammatory effects of a walnut (Juglans regia L.) septum extract (WSE), rich in bioactive compounds were investigated using the citric acid aerosol-induced cough experimental model in rodents. Wistar male rats were treated orally for three days with distilled...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830861/ https://www.ncbi.nlm.nih.gov/pubmed/33467612 http://dx.doi.org/10.3390/antiox10010119 |
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author | Fizeșan, Ionel Rusu, Marius Emil Georgiu, Carmen Pop, Anca Ștefan, Maria-Georgia Muntean, Dana-Maria Mirel, Simona Vostinaru, Oliviu Kiss, Béla Popa, Daniela-Saveta |
author_facet | Fizeșan, Ionel Rusu, Marius Emil Georgiu, Carmen Pop, Anca Ștefan, Maria-Georgia Muntean, Dana-Maria Mirel, Simona Vostinaru, Oliviu Kiss, Béla Popa, Daniela-Saveta |
author_sort | Fizeșan, Ionel |
collection | PubMed |
description | The antitussive, antioxidant, and anti-inflammatory effects of a walnut (Juglans regia L.) septum extract (WSE), rich in bioactive compounds were investigated using the citric acid aerosol-induced cough experimental model in rodents. Wistar male rats were treated orally for three days with distilled water (control), codeine (reference), and WSE in graded doses. On the third day, all rats were exposed to citric acid aerosols, the number of coughs being recorded. Each animal was sacrificed after exposure, and blood and lung tissue samples were collected for histopathological analysis and the assessment of oxidative stress and inflammatory biomarkers. The results of the experiment showed a significant antitussive effect of WSE, superior to codeine. This activity could be due to cellular protective effect and anti-inflammatory effect via the stimulation of the antioxidant enzyme system and the decrease of IL-6 and CXC-R1 concentration in the lung tissue of WSE-treated animals. The antioxidant and anti-inflammatory effects of WSE were confirmed by biochemical assays and histopathological analysis. This is the first scientific study reporting the antitussive effect of walnut septum, a new potential source of non-opioid antitussive drug candidates, and a valuable bioactive by-product that could be used in the treatment of respiratory diseases. |
format | Online Article Text |
id | pubmed-7830861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78308612021-01-26 Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds Fizeșan, Ionel Rusu, Marius Emil Georgiu, Carmen Pop, Anca Ștefan, Maria-Georgia Muntean, Dana-Maria Mirel, Simona Vostinaru, Oliviu Kiss, Béla Popa, Daniela-Saveta Antioxidants (Basel) Article The antitussive, antioxidant, and anti-inflammatory effects of a walnut (Juglans regia L.) septum extract (WSE), rich in bioactive compounds were investigated using the citric acid aerosol-induced cough experimental model in rodents. Wistar male rats were treated orally for three days with distilled water (control), codeine (reference), and WSE in graded doses. On the third day, all rats were exposed to citric acid aerosols, the number of coughs being recorded. Each animal was sacrificed after exposure, and blood and lung tissue samples were collected for histopathological analysis and the assessment of oxidative stress and inflammatory biomarkers. The results of the experiment showed a significant antitussive effect of WSE, superior to codeine. This activity could be due to cellular protective effect and anti-inflammatory effect via the stimulation of the antioxidant enzyme system and the decrease of IL-6 and CXC-R1 concentration in the lung tissue of WSE-treated animals. The antioxidant and anti-inflammatory effects of WSE were confirmed by biochemical assays and histopathological analysis. This is the first scientific study reporting the antitussive effect of walnut septum, a new potential source of non-opioid antitussive drug candidates, and a valuable bioactive by-product that could be used in the treatment of respiratory diseases. MDPI 2021-01-15 /pmc/articles/PMC7830861/ /pubmed/33467612 http://dx.doi.org/10.3390/antiox10010119 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fizeșan, Ionel Rusu, Marius Emil Georgiu, Carmen Pop, Anca Ștefan, Maria-Georgia Muntean, Dana-Maria Mirel, Simona Vostinaru, Oliviu Kiss, Béla Popa, Daniela-Saveta Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds |
title | Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds |
title_full | Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds |
title_fullStr | Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds |
title_full_unstemmed | Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds |
title_short | Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds |
title_sort | antitussive, antioxidant, and anti-inflammatory effects of a walnut (juglans regia l.) septum extract rich in bioactive compounds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830861/ https://www.ncbi.nlm.nih.gov/pubmed/33467612 http://dx.doi.org/10.3390/antiox10010119 |
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