The Added Value of [(18)F]FDG PET/CT in the Management of Invasive Fungal Infections

Anatomy-based imaging methods are the usual imaging methods used in assessing invasive fungal infections (IFIs). [(18)F]FDG PET/CT has also been used in the evaluation of IFIs. We assessed the added value of [(18)F]FDG PET/CT when added to the most frequently used anatomy-based studies in the evaluation of IFIs. The study was conducted in two University Medical Centers in the Netherlands. Reports of [(18)F]FDG PET/CT and anatomy-based imaging performed within two weeks of the [(18)F]FDG PET/CT scan were retrieved, and the presence and sites of IFI lesions were documented for each procedure. We included 155 [(18)F]FDG PET/CT scans performed in 73 patients. A total of 216 anatomy-based studies including 80 chest X-rays, 89 computed tomography studies, 14 magnetic resonance imaging studies, and 33 ultrasound imaging studies were studied. The anatomy-based studies were concordant with the [(18)F]FDG PET/CT for 94.4% of the scans performed. [(18)F]FDG PET/CT detected IFI lesions outside of the areas imaged by the anatomy-based studies in 48.6% of the scans. In 74% of the patients, [(18)F]FDG PET/CT added value in the management of the IFIs.