Cargando…

Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study

The use of high dose ascorbate infusions in cancer patients is widespread, but without evidence of efficacy. Several mechanisms whereby ascorbate could affect tumor progression have been proposed, including: (i) the localized generation of cytotoxic quantities of H(2)O(2); (ii) ascorbate-dependent a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dachs, Gabi U., Gandhi, Jamish, Wohlrab, Christina, Carr, Anitra C., Morrin, Helen R., Pullar, Juliet M., Bayer, Simone B., Eglinton, Tim W., Robinson, Bridget A., Vissers, Margreet C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830882/ https://www.ncbi.nlm.nih.gov/pubmed/33505915 http://dx.doi.org/10.3389/fonc.2020.600715

Ejemplares similares

Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals
por: M. Pullar, Juliet, et al.
Publicado: (2020)

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein
por: Wohlrab, Christina, et al.
Publicado: (2018)

Marginal Ascorbate Status (Hypovitaminosis C) Results in an Attenuated Response to Vitamin C Supplementation
por: Carr, Anitra C., et al.
Publicado: (2016)

Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells
por: Wohlrab, Christina, et al.
Publicado: (2019)

Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels
por: Campbell, Elizabeth J., et al.
Publicado: (2019)

Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations(1)(2)(3)
por: Carr, Anitra C, et al.
Publicado: (2013)

Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival
por: Burgess, Eleanor R., et al.
Publicado: (2022)

The Roles of Vitamin C in Skin Health
por: Pullar, Juliet M., et al.
Publicado: (2017)

Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics
por: White, Rebecca, et al.
Publicado: (2020)

Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine
por: Crake, Rebekah L. I., et al.
Publicado: (2022)

Bioavailability of vitamin C from kiwifruit in non-smoking males: determination of ‘healthy’ and ‘optimal’ intakes
por: Carr, Anitra C., et al.
Publicado: (2012)

Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(−/−) mice
por: Campbell, Elizabeth J, et al.
Publicado: (2015)

Mood improvement in young adult males following supplementation with gold kiwifruit, a high-vitamin C food
por: Carr, Anitra C., et al.
Publicado: (2013)

Enhanced Human Neutrophil Vitamin C Status, Chemotaxis and Oxidant Generation Following Dietary Supplementation with Vitamin C-Rich SunGold Kiwifruit
por: Bozonet, Stephanie M., et al.
Publicado: (2015)

High Vitamin C Status Is Associated with Elevated Mood in Male Tertiary Students
por: Pullar, Juliet M., et al.
Publicado: (2018)

Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo(−/−) mice
por: Campbell, Elizabeth J, et al.
Publicado: (2016)

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer
por: Kuiper, Caroline, et al.
Publicado: (2014)

Ascorbate Uptake and Retention by Breast Cancer Cell Lines and the Intracellular Distribution of Sodium-Dependent Vitamin C Transporter 2
por: Praditi, Citra, et al.
Publicado: (2023)

Appropriate Handling, Processing and Analysis of Blood Samples Is Essential to Avoid Oxidation of Vitamin C to Dehydroascorbic Acid
por: Pullar, Juliet M., et al.
Publicado: (2018)

A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C
por: Carr, Anitra C., et al.
Publicado: (2013)

The Effect of Intravenous Vitamin C on Cancer- and Chemotherapy-Related Fatigue and Quality of Life
por: Carr, Anitra C., et al.
Publicado: (2014)

Gene and Protein Expression Is Altered by Ascorbate Availability in Murine Macrophages Cultured under Tumour-Like Conditions
por: Ang, Abel D., et al.
Publicado: (2021)

Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1
por: Flett, Teresa, et al.
Publicado: (2014)

Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration
por: Pearson, Andree G., et al.
Publicado: (2021)

Synthetic or Food-Derived Vitamin C—Are They Equally Bioavailable?
por: Carr, Anitra C., et al.
Publicado: (2013)

Current Limitations of Murine Models in Oncology for Ascorbate Research
por: Campbell, Elizabeth J., et al.
Publicado: (2014)

Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study
por: Pearson, John F., et al.
Publicado: (2017)

A Randomised Cross-Over Pharmacokinetic Bioavailability Study of Synthetic versus Kiwifruit-Derived Vitamin C
por: Carr, Anitra C., et al.
Publicado: (2013)

Vitamin C and immune cell function in inflammation and cancer
por: Ang, Abel, et al.
Publicado: (2018)

Effect of intravenous vitamin C on arterial blood gas analyser and Accu-Chek point-of-care glucose monitoring in critically ill patients
por: Rosengrave, Patrice C., et al.
Publicado: (2023)

Neutrophils Isolated from Septic Patients Exhibit Elevated Uptake of Vitamin C and Normal Intracellular Concentrations despite a Low Vitamin C Milieu
por: Carr, Anitra C., et al.
Publicado: (2021)

Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge
por: Wohlrab, Christina, et al.
Publicado: (2017)

Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression
por: Kuiper, Caroline, et al.
Publicado: (2014)

Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate
por: Das, Andrew B., et al.
Publicado: (2020)

Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomized controlled trial
por: Conner, Tamlin S., et al.
Publicado: (2017)

Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge
por: Carr, Anitra C., et al.
Publicado: (2018)

Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?
por: Carr, Anitra C., et al.
Publicado: (2015)

The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response
por: Crake, Rebekah L. I., et al.
Publicado: (2021)

Initial Evidence of Variation by Ethnicity in the Relationship between Vitamin C Status and Mental States in Young Adults
por: Fletcher, Benjamin D., et al.
Publicado: (2021)

KiwiC for Vitality: Results of a Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Tablets on Vitality in Adults with Low Vitamin C Levels
por: Conner, Tamlin S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ncqol1l37gqjuqgea3456rnd5c